Antiphospholipid antibodies proposed in the diagnosis of infective endocarditis |
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| Authors: | C. Zaratzian F. Gouriet H. Tissot-Dupont J.-P. Casalta M. Million N. Bardin D. Grisoli G. Habib D. Raoult |
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| Affiliation: | 1.UM63, CNRS 7278, IRD 198, INSERM 1095 IHU - Méditerranée Infection,Aix-Marseille Université,Marseille Cedex 05,France;2.Immunology Laboratory, Centre Hospitalier Universitaire, H?pital de la Conception, AP-HM,Aix-Marseille University,Marseille,France;3.Department of Cardiac Surgery, Centre Hospitalier Universitaire, H?pital de La Timone, AP-HM,Aix-Marseille University,Marseille,France;4.Department of Cardiology, Centre Hospitalier Universitaire, H?pital de La Timone, AP-HM,Aix-Marseille University,Marseille,France |
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| Abstract: | Antiphospholipid antibodies (aPL) may occur alone or associated with other diseases. To evaluate aPL, tested as anticardiolipin antibodies (IgG aCL) in infective endocarditis (IE) diagnosis, we investigated their prevalence in a cohort of 651 patients with IE suspicion. aPL was significantly associated with definite IE versus IE-rejected patients. Their mean levels were significantly higher in patients with definite IE versus possible IE. When applied as Duke minor criterion, they were significantly more often positive, and at higher levels, in patients with definite IE than in patients with possible or rejected IE. aPL could be helpful in difficult cases of IE diagnosis. |
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