Improved renal allograft survival with vitamin D receptor polymorphism |
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Authors: | Lavin P J Laing M E O'Kelly P Moloney F J Gopinathan D Aradi A Al Shields D C Murphy G M Conlon P J |
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Affiliation: | Department of Nephrology, Beaumont Hospital, Dublin 9, Ireland. plavin@chg.duhs.duke.edu |
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Abstract: | BACKGROUND: Polymorphisms in genes, coding for proteins involved in immune response, or the pathogenesis of atherosclerosis may influence immunological and non-immunological mechanisms that lead to allograft loss. Vitamin D receptor (VDR) agonists reduce allograft rejection in animal models, and there are a number of functional polymorphisms in VDR. METHODS: In all, 379 renal transplant recipients were genotyped for VDR (FokI & ApaI) polymorphisms, and the association of each genotype with renal allograft survival and acute rejection was determined. RESULTS: There was significantly improved allograft survival for patients who were homozygous or heterozygous for the VDR FokI T allele (Hazard Ratio [HR] = 0.488, p < 0.001). CONCLUSION: The association of VDR FokI T allele with improved renal allograft survival is a unique observation. The finding is in keeping with data showing the prevention of chronic allograft rejection with the use of Vitamin D receptor agonists. |
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