| 肉毒碱／有机阳离子转运体基因多态性与克罗恩病相关性的研究进展 |
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| 引用本文： | 卢战军,郑萍. 肉毒碱／有机阳离子转运体基因多态性与克罗恩病相关性的研究进展[J]. 胃肠病学, 2008, 13(1): 61-63 |
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| 作者姓名： | 卢战军 郑萍 |
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| 作者单位： | 上海交通大学附属第一人民医院消化内科,200080 |
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| 摘 要： | 克罗恩病（CD）是肠道慢性、节段性、透壁性、肉芽肿性炎症性疾病，其发病机制尚未明确，但遗传因素在CD的发病中起重要作用。近年研究将位于5号染色体上的肉毒碱，有机阳离子转运体（OCTN）1和OCTN2确认为CD易感基因，本文就OCTN基因多态性与CD相关性的研究进展作一综述。
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| 关 键 词： | Crohn病 肉碱 有机阳离子转运子1 多态现象 遗传 |
| 修稿时间： | 2007-07-31 |
Development of Relationship between Carnitine/Organic Cation Transporter Gene Polymorphism and Crohn''''s Disease |
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| LU Zhanjun,ZHENG Ping. Development of Relationship between Carnitine/Organic Cation Transporter Gene Polymorphism and Crohn''''s Disease[J]. Chinese Journal of Gastroenterology, 2008, 13(1): 61-63 |
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| Authors: | LU Zhanjun ZHENG Ping |
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| Affiliation: | LU Zhanjun, ZHENG Ping.( Department of Gastroenterology, The First People＇s Hospital, Shanghai Jiaotong University, Shanghai (200080)) |
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| Abstract: | Crohn＇s disease （CD） is an inflammatory bowel disease characterized by chronic, segmental, transmural, and granulomatous inflammation, its pathogenesis remains unclear, however, genetic factor plays an important role in the pathogenesis of CD. Recent studies have identified carnitine/organic cation transporter （OCTN） 1 and OCTN2 on chromosome 5 as the CD susceptibility genes. This review article introduced the development of relationship between OCTN gene polymorphism and CD. |
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| Keywords: | Crohn Disease Carnitine Organic Cation Transporter 1 Polymorphism, Genetic |
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