丹参联合厄贝沙坦治疗糖尿病肾病尿蛋白的临床观察

目的总结丹参注射液联合厄贝沙坦治疗糖尿病肾病的疗效。方法将60例Ⅲ期糖尿病患者分成治疗组和对照组各30例,对照组在糖尿病原治疗方案上加用厄贝沙坦片．治疗组加用厄贝沙坦片和丹参注射液,疗程1个月。观察患者24h尿白蛋白的排泄率（UAER）、尿β2微球蛋白（β2-MG）及血液流变学的改变。结果治疗组治疗后的UARE、β2-MG及血压与治疗前比较,明显下降,差异均有统计学意义（t分别=0．72、0．83、1．02、0．86,P均〈0．05）;与对照组治疗后比较,差异也均有统计学意义（t分别=0．76、0．93、2．03、1.24,P均〈0．05）。治疗组治疗后的血浆粘度、红细胞压积、全血低切、全血高切、纤维蛋白原指标比治疗前有所下降．差异均有统计学意义（t分别=0．76、0．79、1．05、0．85、0．98,P均〈0．05）：与对照组治疗后比较,差异也均有统计学意义（t分别=0．81、0．85、0．94、1．25、0．98,P均〈0．05）。结论丹参注射液联合厄贝沙坦治疗能有效降低糖尿病肾病的尿蛋白的排泄,又能改善血液流变学,对糖尿病肾病的病程进展有一定防治作用。

Effects of salvia injection and irbesartan on urine protein in patients with diabetic neplaropathy

Objective To explore the effects of salvia injection and irbesartan on urine protein in patients with diabetic nephropathy. Methods Sixty patients in stage Ⅲ were divided into two groups： treatment group and control group （30 each）. The treatment group was treated by irbesartan tablets and salvia mihiorrhiza injection for one month; the control group had treatment with additional irbesartan tablets. Urinary albumin excretion rate （UAER）, urine β2 micro globulin （β2-MG） and the change of blood rheology were observed for 24 hours. Results There were statistic differences in UARE, β2-MG and blood pressure before and after treatment in the treatment group （t=0.72, 0.83, 1.02, 0.86, P〈0.05）. UARE, β2-MG and blood pressure in the treatment group had statistic differences compared with that of the control group after treatment （t= 0.76, 0.93, 2.03, 1.24, P〈0.05）. PV, HCT, LBV,HBV, fibrinogen index were decreased after treatment in the treatment group and there were statistic differences compared with that of before treatment （t= 0.76, 0.79, 1.05, 0.85, 0.98, P〈0.05） and comparing with the control group after treatment there were statistic differences （t=0.81, 0.85, 0.94, 1.25, 0.98, P〈0.05）. Conclusions The treatment of irbesartan and salvia mihiorrhiza injection can effectively reduce the urinary protein excretion, improve the blood rheology and has certain preventive effect on the progression of diabetic nephropathy.