| 贯叶连翘提取物对慢性应激抑郁大鼠行为及脑内5-HT、NE表达的影响 |
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| 引用本文： | 贯叶连翘提取物对慢性应激抑郁大鼠行为及脑内5-HT、NE表达的影响[J]. 中国药科大学学报, 2003, (1): 72-75. |
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| 作者姓名： | 司银楚 孙建宁 |
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| 作者单位： | 1. 北京中医药大学解剖教研室,北京,100029
2. 北京中医药大学药理教研室,北京,100029 |
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| 摘 要： | 目的：研究贯叶连翘提取物对抑郁大鼠行为学及脑内5－羟色胺（5－HT）、去甲肾上腺素（NE）表达的影响。方法：采用大鼠慢性应激抑郁模型、灌胃给药、行为学及免疫组织化学方法。结果：贯叶连翘提取物各剂量可显著增加慢性应激抑郁模型大鼠糖水摄入量，敞箱行为实验走格数与站立数，显著减少跳台逃避实验错误反应的停留期以及明显增强5－HT、NE在大鼠脑内的表达。结论：贯叶连翘提取物通过增强抑郁大鼠脑内NE和5－HT表达，从而改善抑郁症状，达到治疗目的。
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| 关 键 词： | 贯叶连翘提取物 慢性应激 抑郁 大鼠 行为学 5－羟色胺 去甲肾上腺素 |
| 文章编号： | 1000-5048(2003)01-0070-04 |
| 修稿时间： | 2002-05-23 |
Effects of Hypericin on Behavior and Expression of 5-HT and NE in Brain of Depression Rat with Chronic Stress |
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| Effects of Hypericin on Behavior and Expression of 5-HT and NE in Brain of Depression Rat with Chronic Stress[J]. Journal of China Pharmaceutical University, 2003, (1): 72-75. |
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| Authors: | SI Yin Chu SUN Jian Ning |
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| Affiliation: | SI Yin Chu 1,SUN Jian Ning 2 1Department of Anatomy, 2Department of Pharmacology,Beijing University of TCM,Beijing 100029,China |
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| Abstract: | AIM:The purpose is to study the effects of hypericin on behavior and expression of 5 HT,and NE in depression rat brain.METHOD:This study adapted the depression rat model of chronic stress, behavior and immunohistochemistry. RESULT:Hypericin can increase depression rats notably crossing and roaring in open field behavior test, decrease stop period of error reaction in step down avoidance behavior test, increase the expression of 5 HT, NE in rat brain. CONCLUSION:Hypericin could improve depression through increasing expression of NE and 5 HT in depression rat brain. |
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| Keywords: | Hypericin Depression Behavior 5 HT NE |
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