羊膜腔内注射地塞米松促胎肺成熟135例研究

目的 观察羊膜腔内注射地塞米松促胎肺成熟的效果。方法将231例高危妊娠产妇随机分为两组，治疗组135例，羊膜腔内注射地塞米松，对照组96例，常规治疗，治疗结果做卡方检验处理。结果新生儿RDS发生率、新生儿死亡率以及死于呼吸系统疾病的比率，用药组分剐为14．8％、7．4％和30％，明显低于对照组的29．2％、21．9％和76．1％(P<0．01)。结论羊膜腔内注射地塞米松具有明显的促胎肺成熟作用。

Study of 135 Patients on Intra-amniotic Injection of Dexamethasone Promoting Fetal Lung Maturation

Objective To observe the effect in promoting fetal lung maturation by intra-amniotic injection of Dexamethasone. Methods 231 high risk pregnant parturients were divided into the therapeutic group and the control group randomly.The therapeutic group (135 parturients) was given intra-amniotic injection of Dexamethasone,while the control group (96 parturients) was given routine treatment. Statistical analysis was applied in the therapeutic result. Results New-born RDS incidence rate, death rate and ratio of death due to respiratory disease were significantly reduced in the therapeutic group (14.8%, 7.4% and 30% respectively) than the control group (29.2%,21.9% and 76.1% respectively) (P <0.01). Conclusion It can significantly promote fetal lung maturation to intra-amniotically inject Dexamethasone.