| Hormone Regulation of Tissue Type Piasminogen Activator （tPA） and Plasminogen Activator Inhibitor Type I （PAI-I） Gene Expression in the Ovaries During Gonadotropin-induced Ovulation |
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| 作者姓名： | 刘以训 冯强 邹如金 彭晓蓉 薛人望 陶尼 |
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| 作者单位： | [1]StateKeyLaboratoryofReproductiveBiofogy,InstituteofZoofogy,ChineseAcademyofSciences,Beijing100080,P.R.China [2]DepartmentofAppliedCellandMolecularBiology,UmeaUniversity,S-90187Umea,Sweden [3]DivisionofReproductiveBiology,DepartmentofObstetricsandGynecology,StanfordUniversity,SchoolofMedicine,300PasteurDrive,Stanford,CA94305-5317,USA |
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| 摘 要： | The plasminogen-activator system provides proteolytic activity in many biological processes . The regulation of plasminogen activation may occur at many levels in-cluding the synthesis and secretion of plasminogen activators (PA) and the specific in-hibition of PA activity by inhibitors. PA-inhibitor o,pe-1 ( PAI-1) is an efficientinhibitor of tissue-type PA (tPA) and urokinase-type PA (uPA) that may thereforebe instrumental for the control of plasminogen activation . To investigate whethercoordinated regulation of PA an PA inhibitors would take place in vivo in response tophysiological signals, we have examined the regulation of tPA and PAI-1 in the ovaryduring gnnadotropin-induced ovulation.
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| 关 键 词： | 荷尔蒙调节 血浆酶原 抑制剂 卵巢 促性腺激素 |
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