| 甲基莲心碱对耐阿霉素人乳腺癌细胞内阿霉素积累的影响 |
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| 引用本文： | 董琳,唐小卿,曹建国,王佐.甲基莲心碱对耐阿霉素人乳腺癌细胞内阿霉素积累的影响[J].中国药理学通报,2002,18(1):43-45. |
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| 作者姓名： | 董琳 唐小卿 曹建国 王佐 |
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| 作者单位： | 1. 南华大学,肿瘤医学研究所,衡阳,421001
2. 南华大学,心血管病研究所,衡阳,421001 |
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| 基金项目： | 湖南省教委科研基金资助课题 ,No 96 15 5 |
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| 摘 要： | 目的 研究甲基莲心碱 (Nef)对耐阿霉素人乳腺癌细胞MCF 7/Adr内阿霉素 (ADM )积累的影响。方法 MTT法检测Nef对多药耐药性 (MDR)的逆转作用 ,高效液相色谱 (HPLC)法检测细胞内阿霉素浓度。结果 Nef能降低阿霉素对MCF 7/Adr细胞IC50 值 ,能提高MCF 7/Adr细胞内ADM的浓度。结论 Nef逆转MCF 7/Adr细胞多药耐药的机制与其增加多药耐药细胞内抗癌药物积累有关。
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| 关 键 词： | 甲基莲心碱 多药耐药 阿霉素 |
| 文章编号： | 1001-1978(2002)01-0043-03 |
Effect of neferine on intracellular adriamycin accumulation in MCF-7/Adr cell line |
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| DONG Ling,TANG Xiao-Qing,CAO Jian-Guo,WANG Zuo.Effect of neferine on intracellular adriamycin accumulation in MCF-7/Adr cell line[J].Chinese Pharmacological Bulletin,2002,18(1):43-45. |
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| Authors: | DONG Ling TANG Xiao-Qing CAO Jian-Guo WANG Zuo |
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| Abstract: | AIM To study the effect of neferine on intracellular adriamycin(ADM) accumulation in MCF-7/Adr cell line. METHODS The cytotoxic effect was determined by MTT assay. The intracellular ADM concentration was assayed by HPLC. RESULTS Neferine(Nef) decreased the IC 50 of ADM to MCF-7/Adr cells but increased the intracellular concentration of ADM. CONCLUSION The mechanism of the MDR reversal effect of Nef is associated with the increase of the intracellular accumulation of anticancer drug. |
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| Keywords: | neferine multidrug resistance Adriamycin |
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