Anchorless keratinocyte survival: an emerging pathogenic mechanism for squamous cell carcinoma in recessive dystrophic epidermolysis bullosa |
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| Authors: | Rodeck Ulrich Fertala Andrzej Uitto Jouni |
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| Affiliation: | Department of Dermatology and Cutaneous Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA. ulrich.rodeck@mail.jci.tju.edu |
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| Abstract: | Squamous cell carcinomas in patients suffering from recessive dystrophic epidermolysis bullosa are highly invasive and frequently metastatic. Expression of a collagen VII fragment (NC1) has been described as a prerequisite for the development of this tumor form. This commentary focuses on potential molecular mechanisms by which expression of the NC1 fragment may augment anchorage-independent growth and survival of malignant keratinocytes. |
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| Keywords: | carcinoma collagen type VII Epidermolysis bullosa dystrophica signal transduction squamous cell |
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