| 小花异裂菊中的微量新成分 |
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| 引用本文： | 樊晓娜,林生,朱承根,杨永春,石建功.小花异裂菊中的微量新成分[J].药学学报,2010,45(1):82-86. |
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| 作者姓名： | 樊晓娜 林生 朱承根 杨永春 石建功 |
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| 作者单位： | (中国医学科学院、北京协和医学院药物研究所, 中草药物质基础与资源利用教育部重点实验室, 北京 100050) |
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| 基金项目： | supported by the National Natural Sciences Foundation of China (30825044 and 20432030); the Program for Changjiang Scholars and Innovative Research Team in University (IRT0514); the national “973” program of China (2004CB13518906 and 2006CB504701) |
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| 摘 要： | 通过硅胶和Pharmadex LH-20凝胶柱色谱以及反相HPLC等多种分离技术的组合应用, 从小花异裂菊全草乙醇提取物中分离得到了2个微量新化合物: 半日花烷-12, 14-二烯-6β, 7α, 8β, 17-四醇 (1) 和2, 3-顺式-6-乙酰基-5-羟基-2-(羟甲基乙烯基)-2, 3-二氢苯并呋喃-3-醇当归酸酯 (2), 以及1个微量新天然产物: 6-甲氧基-4-甲基-3, 4-二氢-2H-1-萘酮 (3)。运用包括二维核磁共振实验的波谱学数据解析确定了它们的结构。
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| 关 键 词： | 小花异裂菊 微量成分 二萜 苯并呋喃衍生物 3 4-二氢-2H-萘-1-酮衍生物 |
Minor new constituents from Heteroplexis micocephala |
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| FAN Xiao-na,LIN Sheng,ZHU Cheng-gen,YANG Yong-chun,SHI Jian-gong.Minor new constituents from Heteroplexis micocephala[J].Acta Pharmaceutica Sinica,2010,45(1):82-86. |
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| Authors: | FAN Xiao-na LIN Sheng ZHU Cheng-gen YANG Yong-chun SHI Jian-gong |
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| Institution: | FAN Xiao-na,LIN Sheng,ZHU Cheng-gen,YANG Yong-chun,SHI Jian-gong (Key Laboratory of Bioactive Substances , Resources Utilization of Chinese Herbal Medicine,Ministry of Education of PRC,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100050,China) |
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| Abstract: | By using a combination of various chromatographic techniques including column chromatography over silica gel and Pharmadex LH-20 and reversed-phase HPLC, two minor new compounds, labda-12, 14-dien- 6β, 7α, 8β, 17-tetraol (1), 2, 3-cis-6-acetyl-5-hydroxy-2-(hydroxymethylvinyl)-2, 3-dihydrobenzofuran-3-ol angelate (2), and a minor new natural product 6-methoxy-4-methyl-3, 4-dihydro-2H-naphthalen-1-one (3) have been isolated from an ethanolic extract of Heteroplexis micocephala. Their structures were elucidated with spectroscopic data analysis including 2D NMR experiments. |
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| Keywords: | Heteroplexis micocephala minor constituent diterpene benzofuran derivative 3 4-dihydro-2H-naphthalen-1-one derivative |
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