| 心房颤动对不同心功能分级的患者血浆脑钠肽水平的影响 |
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| 引用本文： | 潘文志,巩雪,周京敏,舒先红,宿燕岗,葛均波. 心房颤动对不同心功能分级的患者血浆脑钠肽水平的影响[J]. 中华心律失常学杂志, 2001, 13(1): 213-216. DOI: 10.3760/cma.j.issn.1007-6638.2009.03.014 |
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| 作者姓名： | 潘文志 巩雪 周京敏 舒先红 宿燕岗 葛均波 |
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| 作者单位： | 复旦大学附属中山医院心内科,上海,200032; |
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| 基金项目： | 国家自然科学基金国家科技支撑计划 |
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| 摘 要： | Objective To assess the effect of atrial fibriUation (AF) on plasma levels of NT-proBNP in patients with different cardiac functions. Methods One hundred and ninty-one patients with chronic heart failure (CHF) were divided into two groups: minor CHF group (NYHA Ⅰ/Ⅱ class) and sever CHF group (NYHA Ⅲ/Ⅳ class). In addition,84 patients without HF (non-HF group) were enrolled as control The plas-ma NT-proBNP were assayed and the effect of AF on the NT-proBNP levels was analyzed to determine inde-pendent of NT-proBNP levels in 3 groups. Results Patients with AF in non-HF had higher NT-proBNP levels than those with sinus rhythm (SR) [(2.95 ±0.41) vs (2.21±0.44) ng/L, P < 0.01], and multi-variables regression demonstrated that age, AF and left atrial diameter (LAD) were independent determinants of NT-proBNP levels (P <0.001). NT-proBNP levels in minor CHF were also higher in patients with AF than that in patients with SR [(3.26±0.40) ng/L vs (2.98±0.54) ng/L, P < 0.05] ; AF, LAD, left ventricular end-systolic dimension (LVESD) and left vontric-ular eject fraction (LVEF) were the independent factors of NT-proBNP levels (P < 0.05). However, there was no difference of NT-proBNP levels between patients with AF and patients with SR [(3.59±0.52) ng/L vs (3.56±0.55) ng/L,P =0.73] ; while age and LVEF were in-dependent factors (P < 0.05). In patients with LVEF < 0.40, AF had not significant affect on NT-proBNP lev-els [AF vs SR: (3.70±0.60) ng/L vs (3.46±0.56) ng/L,P >0.10]; however,AF patients with LVEF≥ 0.40, NT-proBNP levels were increased [AF vs SR: (3.08 ±0.57) ng/L vs (2.67±0.73) ng/L, P < 0.001]. Conclusion The effect of AF on plasma NT-proBNP was related with cardiac functions: in AF pa-tients without or with minor cardiac dysfunction (NYHA Ⅰ /Ⅱ class or LVEF≥0.40) ,NT-proBNP increased; in AF patients with sever cardiac dysfunction (NYHA Ⅲ/Ⅳ class or LVEF < 0.40), NT-proBNP had no sig-nificant changes.
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| 关 键 词： | 血浆脑钠肽 心房颤动 慢性心力衰竭 纽约心功能分级 |
Effect of atrial fibrillation on plasma NT-proBNP in patients with different cardiac functions PAN |
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| Wen zhi,GONG Xue,ZHOU Jing-min,SHU Xian-hong,SU Yan-gang,GE Jun-bo. Effect of atrial fibrillation on plasma NT-proBNP in patients with different cardiac functions PAN[J]. Chinese Journal of Cardiac Arrhythmias, 2001, 13(1): 213-216. DOI: 10.3760/cma.j.issn.1007-6638.2009.03.014 |
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| Authors: | Wen zhi GONG Xue ZHOU Jing-min SHU Xian-hong SU Yan-gang GE Jun-bo |
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| Abstract: | |
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| Keywords: | NT-proBNPAtrial fibrillationChronic heart failureNYHA class cardiac function |
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