GRE T2*序列中T2*值的测量在鉴别诊断颅内出血和钙化的应用

目的　研究GRE T2*WI(扰相梯度双回波T2*WI)序列诊断与鉴别诊断颅内出血和钙化的定量分析指标。方法　以ESWAN作为金标准，对已确诊脑出血的18例38个病灶和颅内钙化7例11个病灶进行磁共振GRE T2*WI (15/30 ms)检查。测量不同病灶T2*值，进行统计学分析比较。结果GRE T2*WI序列对于血肿的发现率为CT的1.9倍，对微出血及脑干、小脑等部位出血GRE T2*WI比CT检查更有优势。出血（核心区）与钙化的T2*值有明显的统计学差异（p<0.001），但是出血（外周区）与钙化的T2*值无明显的统计学差异（P > 0.05）。结论　GRE T2*WI序列上颅内出血和钙化T2*值的定量分析,为实现脑血管病的MR一站式诊断奠定了基础。

Application of T2* measurement on GRE T2*-weighted imaging in differential diagnosis of intracranial hemorrhage and calcification

Background And Purpose: To study the feasibility of T2* measurement on GRE T2*WI in differential diagnosis of intracranial hemorrhage and calcification. Methods: Thirty-eight hemorrhagic foci in 18 patients and 11 calcification foci in 7 patients were assessed with GRE T2*WI (15/30 ms) in terms of T2* value. Results: The detection rate of GRE T2*WI on intracranial hemorrhage was 1.9-fold higher than that of CT, especially for the hemorrhage in the brainstem and cerebellum. However, GRE T2*WI was far less sensitive to calcification than CT. There was a significant difference in the T2* value between the central area of hemorrhage and calcification (P < 0.001), though no difference in the T2* value was obtained between the peripheral area of hemorrhage and calcification (P > 0.05).Conclusion: Quantitative measurement of T2* value on GRE T2*WI with a single MRI examination provides a fast, convenient and effective means in differential diagnosis between intracranial hemorrhage and calcification, which may thus reduce the medical cost and save precious time for clinical management.