| DPYD多态性与中国人群胃癌患者应用氟尿嘧啶为基础的辅助化疗的临床结果 |
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| 引用本文： | 张孝平,柏志斌,陈宝安,冯继峰,严峰,姜智,仲悦娇,吴健中,程璐,陆祖宏,仝娜,张振东,许佩佩,彭苗新,张文静,王帅. DPYD多态性与中国人群胃癌患者应用氟尿嘧啶为基础的辅助化疗的临床结果[J]. 中华医学杂志(英文版), 2012, 125(5) |
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| 作者姓名： | 张孝平 柏志斌 陈宝安 冯继峰 严峰 姜智 仲悦娇 吴健中 程璐 陆祖宏 仝娜 张振东 许佩佩 彭苗新 张文静 王帅 |
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| 作者单位： | Department of Hematology and Oncology, Zhongda Hospital, Medical School, Southeast University,Department of General Surgery, Zhongda Hospital, Medical School, Southeast University,Department of Hematology and Oncology, Zhongda Hospital, Medical School, Southeast University,Jiangsu Province Cancer Institute,Jiangsu Province Cancer Institute,Jiangsu Province Cancer Institute,Jiangsu Province Cancer Institute,Jiangsu Province Cancer Institute,National Key Laboratory for Bioelectronics, School of Biological Science and Medical Engineering, Southeast University,National Key Laboratory for Bioelectronics, School of Biological Science and Medical Engineering, Southeast University,Department of Epidemiology and Biostatistics, Nanjing Medical University,Department of Epidemiology and Biostatistics, Nanjing Medical University,Department of Hematology and Oncology, Zhongda Hospital, Medical School, Southeast University,Department of Hematology and Oncology, Zhongda Hospital, Medical School, Southeast University,Department of Hematology and Oncology, Zhongda Hospital, Medical School, Southeast University,Department of Hematology and Oncology, Zhongda Hospital, Medical School, Southeast University |
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| 基金项目： | The National Basic Research Program of China（973 Program, No. 2010CB732404）; Major project fund of Science and technology department of jiangsu province (No. EM2006111); Southeast university science and technology fund (No. KJ2010494). |
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| 摘 要： | 背景:二氢嘧啶还原酶，5-FU代谢的关键酶，是药物遗传学研究5-FU疗效及毒副作用的热点之一。本研究旨在探讨DPYD多态性与中国人群中胃癌患者应用氟尿嘧啶为基础的辅助化疗的临床结果之间的关联性。方法：362名中国胃癌患者应用氟尿嘧啶为基础的方案化疗。采用基于基质辅助激光解吸电离飞行时间质谱技术对治疗前从患者外周血中提取的DNA样本进行DPYD基因单核苷酸多态性的检测。结果：平均化疗有效率为46.7%。rs1801159位点的基因型分布在化疗有效组及无效组中存在显著性差异(χ2=8.76, p=0.012)。其中rs1801159A/A野生纯合子在化疗有效组中更多见，而rs1801159A/G基因型携带者在化疗无效组中更常见。单倍型分析发现两组间的单倍型分布有显著性差异(χ2 = 3.96，p = 0.0465)。结论：rs1801159位点多态性也许可用以预测中国胃癌患者应用氟尿嘧啶为基础的方案的化疗反应，进一步明确DPYD基因多态性的预测价值还需要设计更优的、综合的、前瞻性的研究。
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| 关 键 词： | 胃癌，单核苷酸多态性，二氢嘧啶还原酶基因，氟尿嘧啶 |
The polymorphisms of dihydropyrimidine dehydrogenase gene (DPYD) and clinical outcomes of gastric cancer patients treated with fluorouracil-based adjuvant chemotherapy in Chinese population |
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| Abstract: | |
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| Keywords: | gastric cancer single nucleotide polymorphisms (SNPs) DPYD fluorouracil |
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