高分辨MR结构成像幼儿皮层特征参数与智力发育相关性的初步研究

目的：应用基于高分辨MRI结构成像（sMRI）、表面基础形态测量学（sBM）的皮层测量方法，分析幼儿148个脑区的皮层厚度（CT）、皮层表面积（sA）及平均曲率（AV）等参数，探讨皮层厚度等皮层形态学参数与幼儿智力发育水平的相关性。方法：对13例健康幼儿受试者进行智力发育水平评分。采用Siemens3．0TMR机对所有纳入对象进行高分辨率的3DT。脑结构图像采集。使用基于SBM的方法获取每个被试者148个脑区的CT、SA、AV等参数，逐一对每个脑区皮层参数与幼儿智力发育水平评分进行相关性分析。结果：对受试者大脑半球皮层参数与智力量表评分的相关性分析中发现，sA与智力量表评分存在相关性的脑区集中于语言及社交相关区，即额下回脑沟局部区域，大部分呈负相关，如右脑额下回sA与量表中适应性评分的相关系数r=-0．646（P=0．017），与量表中语言评分的相关系数值r=0．576（P=0．039）；AV与智力量表评分存在相关性的脑区集中于视听、高级整合功能区的颞下回及顶下区，大部分呈负相关，如颞下回AV与量表中精细动作评分的相关系数r=-0．716（P=0．002）；而CT与智力量表评分相关的脑区主要为语言区及与人脸识别相关的侧副横沟前部脑区，呈负相关，如右脑侧副横沟前部CT与量表中语言评分的r值为一0．765（P=0．002）。结论：基于高分辨率MRI并采用SBM测量的幼儿皮层参数与基于智力量表的幼儿智力评分间存在相关性的脑区分布比较广泛，由此可知幼儿大脑结构发育受内在生理因素影响，这与幼儿的智力发育水平、社会适应能力有直接关系。利用这种方法可以对幼儿脑皮层结构进行评估，并可进一步推测幼儿的基本发育状况。

Preliminary study of high resolution MR structural imaging of cerebral cortex in infants and correlated with intelligence deve- lopment

Objective：Using high resolution MRI structural images （sMRI）,surface-based morphometry （SBM） for cortex measurement, to analyze the parameters including cortical thickness （CT）, surface area （SA） and average curvature （AV） 148 cerebral regions,and to study the relationship of cortical morphological parameters （e. g. cortical thickness） and level of intelligence development in infants. Methods： 13 healthy infants were included in the study, their level of intelligence development was evaluated. A siemens 3.0T MR scanner was used to acquire the high resolution 3D T1 WI structural images of brain. The parameters including CT,SA, AV acquired in 148 cerebral regions based on SBM were obtained, the correla- tion of each cortex parameter and the level of intelligence development was analyzed. Results： After analyzing the cortex pa- rameters of all cerebral regions and correlated with intelligence development level scale,it was found that correlation of SA and intelligence development level scores were more concentrated at language and social related regions,ie, gyrus frontalis inferior sulcus region,mostly showed negative correlation. For example,the SA of right gyrus frontalis inferior and the cor- related score coefficient was r= 0. 646 （P= 0. 017） ;the correlated coefficient with the language score was r= 0. 576 （P = 0. 039） ~the cerebral region showed AV correlated with intelligence score was concentrated at gyrus temporalis inferior and parietal inferior,mostly showed negative correlation,for example, the correlated coefficient of AV in gyrus temposalis inferi- or and fine action score was r=0. 716 （P=0. 002） ;the correlated region of CT and intelligence was mainly in the regions of language and recognition of human face,which was the cerebral region anterior to suleus collateralis,showing negative cor- relation. For example,CT anterior to right sulcus collateralis related to language score, r=- 0. 765 （P = 0. 002）. Conclu- sion：Based on high resolution MRI,taking inf