The protease inhibitor TLCK alters the apparent molecular weights of some measles virus proteins by a mechanism unrelated to inhibition of proteolytic cleavage |
| |
| Authors: | S L Wechsler S Weyand A Goosmann B W Burge |
| |
| Affiliation: | Heinrich-Pette-Institut für Experimentelle Virologie and Immunologie an der Universität Hamburg, Martmistrasse 52, 2000 Hamburg 20, Federal Republic of Germany |
| |
| Abstract: | Limited DNase I digestion and subsequent restriction enzyme analysis were used to compare the chromatin conformation of different proviral genome copies in M-MuLV-induced tumors of Mov-3 mice. The results show that the endogenous, genetically transmitted viral genome copy is highly resistant, whereas the somatically acquired genome copies are sensitive to digestion with DNase I. |
| |
| Keywords: | To whom reprint requests should be addressed. |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
