腹膜透析患者C反应蛋白水平与营养状况及心室结构和功能的关系

目的探讨腹膜透析患者C反应蛋白(CRP)水平与营养状况及心室结构和功能的关系。方法选择我院腹透中心稳定的连续性非卧床腹膜透析(CAPD)患者200例,检测其血中CRP水平、血浆白蛋白(ALB)、三酰甘油(TG)、总胆固醇(CHOL)、血红蛋白(Hb),并用彩色心动图测定患者心脏左心房前后径(LAD)、左心室前后径(LVD)、室间隔厚度(IVST)、左心室质量指数(LVMI)、左心室后壁厚度(LVPWT)及左心室射血分数(LVEF)。根据CRP水平分为升高组(CRP>10mg/L)88例及正常组(CRP≤10mg/L)112例,分别观察CRP水平与营养状况及心室结构和功能的关系。结果 CRP升高组Hb、ALB、TG、CHOL低于正常组(P<0.05);CRP升高组LAD、LVD、IVST、LVMI、LVPWT水平明显高于正常组(P<0.05),而LVEF水平明显低于正常组(P<0.05)。CRP水平与LAD、LVD、IVST、LVMI、LVPWT呈正相关(r分别为0.306、0.294、0.310、0.312、0.276,均为P<0.05),而与Hb、ALB、TG、CHOL、LVEF呈负相关(r分别为-0.290、-0.276、-0.284、-0.301、-0.342,均为P<0.05)。结论腹膜透析患者CRP水平与营养状况及心室结构和功能密切相关,CRP水平升高是营养不良及左心室肥厚和功能减退的危险因素。

Peritoneal Dialysis Patients C-Reactlve Protein Level and Nutritional Status and the Structure and Function of Ventricular Relationship

Objective To study the peritoneal dialysis patients C-reactive protein（CRP） level and nutritional status and the structure and function of ventricular relationship. Method Choose abdominal through our stable icontinuity in the center of peritoneal dialysis （CAPD） in 200 eases, detection in its blood CRP level, plasma albumin（ALB）, triglycerides （TG）,total cholesterol （CHOL）,the hemoglobin （Fib）, and such patients were color heart left atrium anteroposterior （LAD）,left ventricular anteroposterior （LVD）,ventrieular septal thickness （IVST）,left entricular mass index （LVMI）,left ventrieular wall thickness （LVPWT） and left ventriicular ejection fraction （LVEF）.Aeeording to the CRP levels are divided into rise group（CRP〉10mg/L）88 example and the normal group（CRP than 10mg/L）in 112 icases, CRP levels were observed and nutritional status and the structure and function of ventricular relationship. Results The CRP rise Hb group,ALB and TG,CHOL below the normal group（P〈0.05）; Elevated CRP group LAD,LVD,IVST,LVMI, LVPWT level was significantly higher than the normal group （P〈0.05）, and obviously lower than normal LVEF level group（P〈0.05）. CRP level and LAD,LVD,IVST, LVMI,LVPWT positively related （r were 0.306,0.294, 0.310,0.312,0.276,are all P〈0.05）,and with Hb,ALB and TG,CHOL,LVEF was negatively related （r-0.290,respeictively-0.276,0.284,0.301,0.342,are all P 〈0.05）. Conclusion Peritoneal dialysis patients CRP level and nutritional status and ventricular structure and function closely related,the CRP levels rise is malnutrition and left ventricular hypertrophy and function to drop risk factors.