| APOE基因多态性与阿尔茨海默病关系研究的进展 |
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| 引用本文： | 马玉梅,张振馨. APOE基因多态性与阿尔茨海默病关系研究的进展[J]. 基础医学与临床, 2007, 27(7): 739-744 |
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| 作者姓名： | 马玉梅 张振馨 |
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| 作者单位： | 中国医学科学院,中国协和医科大学,北京协和医院,神经内科,北京,100730;山东大学,医学院,山东,济南,250012;中国医学科学院,中国协和医科大学,北京协和医院,神经内科,北京,100730 |
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| 摘 要： | 载脂蛋白E(apolipoprotein E,APOE)基因在阿尔茨海默病(Alzheimer disease,AD)的研究中起着重要作用,已经明确APOE基因与老年性痴呆病关系密切。近年来,人们利用分子生物学技术对普通人群及患者APOE基因多态性与AD的关系进行了广泛的研究。笔者就此领域的研究进展做一综述,以期为AD相关研究提供基础信息。
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| 关 键 词： | 载脂蛋白E基因 阿尔茨海默病 多态性 |
| 文章编号： | 1001-6325（2007）07-0739-06 |
| 收稿时间： | 2007-05-09 |
| 修稿时间： | 2007-04-18 |
Recent progress in the study of the relationship between APOE gene polymorphism and Alzheimer disease |
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| MA Yu-mei,ZHANG Zhen-xin. Recent progress in the study of the relationship between APOE gene polymorphism and Alzheimer disease[J]. Basic Medical Sciences and Clinics, 2007, 27(7): 739-744 |
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| Authors: | MA Yu-mei ZHANG Zhen-xin |
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| Abstract: | The Apolipoprotein E(APOE)gene plays important roles in the pathogenesis of the Alzheimer disease(AD).It is clear that APOE gene is closely related with dementia in the elderly.In recent years,extensive researches regarding the relationship between APOE gene polymorphism and AD has been conducted in both health population and patients with AD using molecular biology technique.This paper reviewed the progress in this field for sharing some fundamental information on the research in AD. |
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| Keywords: | APOE gene alzheimer disease polymorphism |
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