尼莫地平对脑出血患者血浆ET-1和CGRP影响的临床探讨

目的：探讨脑出血患者血浆ET-1和CGRP变化以及尼莫地平治疗对血浆ET-1和CGRP的影响。方法：60例脑出血患者随机分为尼莫地平组与常规治疗组，在治疗前后进行血浆ET-1、CGRP水平测定。结果：尼莫地平组和常规治疗组治疗前血浆ET-1和CGRP均显著增高，治疗后明显下降，治疗后血浆ET-1和CGRP降低值尼莫地平组明显高于常规治疗组（P〈0．01）。尼莫地平组与常规治疗组治疗前血肿体积与血浆ET-1和CGRP水平呈显著性正相关，治疗后也呈显著性正相关。结论：脑出血患者血浆ET-1及CGRP水平显著升高，尼莫地平组治疗后明显下降。

Study on the Effect of Nimodipine Treatment on Plasma ET-1 and CGRP Levels in Patients with Cerebral Hemorrhage

Objective To investigate the effect of nimodipine on the changes of plasma ET-1 and CGRP levels in patients with cerebral hemorrhage.Methods Sixty patients with hemorrhage were randomly divided into two groups: nimodipine-treated and conventionally treated(both n=30).The plasma ET-1 and CGRP level were measured both before and after treatment in both groups as well as in 30 controls.Results Plasma levels of ET-1 and CGRP were significantly increased in the patients before treatment and decreased markedly after treatment in both groups.The magnitude of decrease of the plasma ET-1 and CGRP levels in the nimodipine-treated group was significantly larger than that in the conventionally treated group(P<0.01).Size of the hematoma in both groups was positively correlated with the plasma ET-1,CGRP levels both before and after treatment.Conclusion The plasma ET-1 and CGRP levels in patients with cerebral hemorrhage were remarkably increased and markedly decreased after treatment with nimodipine.