保护性肺通气对婴儿围体外循环期肺功能的影响

Objective To investigate the impact of static inflation and intermittent ventilation on lung function peri-cardiopulmonary bypass(CPB) in infants.Methods Sixty infants of less than 1-year-old,with ventricular septal defect were selected to assigned to two groups:the treatment group(n=30),given static inflation and intermittent ventilation once every 10 minutes during CPB;the control group(n = 30),no ventilation during CPB.Indicators of pulmonary function including OI,PaO2/PAO2,A-aDO2 and RI were recorded before CPB and 2 h,6 h,12 h,24 h and 48 h after CPB.Results At 2 h,6 h,12 h after CPB,OI and PaO2/PAO2 of the treatment group were higher than those of the control group(P＜0.05).A-aDO2 of the treatment group was lower than that of the control group at 2 h,6 h,12 h,48 h after CPB(P＜0.05).RI of the treatment group was lower than that of the control group at 6 h,12 h after CPB(P ＜0.05).Conclusion Static inflation and intermittent ventilation during CPB can improve early oxygenation of lung,and have good lung protection in infants.

Influence of static inflation and Intermittent ventilation on lung function during cardiopulmonary bypass in infants