Coffee consumption and risk of cardiovascular events and all-cause mortality among women with type 2 diabetes |
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Authors: | W L Zhang E Lopez-Garcia T Y Li F B Hu R M van Dam |
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Institution: | 1.Department of Nutrition,Harvard School of Public Health,Boston,USA;2.Sino-German Laboratory for Molecular Medicine, FuWai Cardiovascular Hospital and Cardiovascular Institute,Peking Union Medical College and Chinese Academy of Medical Sciences,Beijing,China;3.Universidad Autónoma de Madrid,Madrid,Spain;4.CIBER Epidemiologia y Salud Pública (CIBERESP),Barcelona,Spain;5.Department of Epidemiology,Harvard School of Public Health,Boston,USA;6.Channing Laboratory,Brigham and Women’s Hospital and Harvard Medical School,Boston,USA |
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Abstract: | Aims/hypothesis Coffee has been linked to both beneficial and harmful health effects, but data on its relationship with cardiovascular disease
and mortality in patients with type 2 diabetes are sparse.
Methods This was a prospective cohort study including 7,170 women with diagnosed type 2 diabetes but free of cardiovascular disease
or cancer at baseline. Coffee consumption was assessed in 1980 and then every 2–4 years using validated questionnaires. A
total of 658 incident cardiovascular events (434 coronary heart disease and 224 stroke) and 734 deaths from all causes were
documented between 1980 and 2004.
Results After adjustment for age, smoking and other cardiovascular risk factors, the relative risks were 0.76 (95% CI 0.50–1.14) for
cardiovascular diseases (p trend = 0.09) and 0.80 (95% CI 0.55–1.14) for all-cause mortality (p trend = 0.05) for the consumption of ≥4 cups/day of caffeinated coffee compared with non-drinkers. Similarly, multivariable
RRs were 0.96 (95% CI 0.66–1.38) for cardiovascular diseases (p trend = 0.84) and 0.76 (95% CI 0.54–1.07) for all-cause mortality (p trend = 0.08) for the consumption of ≥2 cups/day of decaffeinated coffee compared with non-drinkers. Higher decaffeinated
coffee consumption was associated with lower concentrations of HbA1c (6.2% for ≥2 cups/day versus 6.7% for <1 cup/month; p trend = 0.02).
Conclusions These data provide evidence that habitual coffee consumption is not associated with increased risk of cardiovascular diseases
or premature mortality among diabetic women.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorised users. |
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Keywords: | Cardiovascular disease Coffee consumption Epidemiology Mortality Nutrition and diet |
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