麻仁软胶囊对便秘的疗效及其安全性考察

目的 观察麻仁软胶囊对便秘的疗效和对结肠黏膜的影响.方法 结肠慢传输型及混合型便秘的门诊患者208例随机分为治疗组及对照组.治疗组患者每日口服麻仁软胶囊1次,每次2粒,连续服用10个月；对照组患者每日口服番泻叶5 g(沸水100 mL浸泡后顿服)1次,连续服用10个月.根据排便次数和胃肠传输实验(GITT)判断治愈率、总显效率(治愈率+显效率)、总有效率(总显效率+有效率).依据腹胀、腹痛等判断不良反应.治疗10个月后肠镜观察结肠黏膜黑变情况.结果 治疗组的治愈率略低于对照组,总显效率、总有效率与对照组无显著差异,治疗组患者服药后10个月后镜检未发现结肠黑变,而对照组26.9％患者结肠黑变.结论 低剂量麻仁软胶囊治疗便秘有效,并具有较高安全性.

Effect and safety of Maren Soft Capsule on constipation

Objective To explore the effect of low-dose Maren Soft Capsule (MSC) on constipation and colonic mucosa. Methods Patients (208 cases) with colon slow transit constipation and mixed constipation were divided into treatment and control groups. MSC (two pills, once daily) and Sennae Folium (5 g) were given to the patients in the treatment and control groups, respectively, for 10 months. The recovery rate, total significant efficiency, and total efficiency were determined by defecation frequency and gastrointestinal transmission experiment. The side effects such as bloating and abdominal pain were observed. Results The recovery rate in the treatment group was lower than that in the control group, and the total significant efficiency and total efficiency were similar to those in the control group. There was no colon melanosis in the treatment group after 10 month, while 26.9% of the patients in the control group were observed with colon melanosis. Conclusion The low-dose MSC has the therapeutic effect on constipation with high safety.