| 2-巯基-5-甲氧基-1H-苯并咪唑的合成 |
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| 引用本文： | 刘雅茹,冯雪松.2-巯基-5-甲氧基-1H-苯并咪唑的合成[J].广东药学院学报,2006,22(1):39-40. |
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| 作者姓名： | 刘雅茹 冯雪松 |
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| 作者单位： | 中国医科大学,药学院,辽宁,沈阳,110001 |
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| 摘 要： | 目的合成奥美拉唑中间体2-巯基-5-甲氧基-1H-苯并咪唑。方法以4-甲氧基-2-硝基苯胺为原料,经锌粉还原后,再与乙基黄原酸钾环缩合制得2-巯基-5-甲氧基-1H-苯并咪唑。结果收率80%。结论该方法简单易行,适合工业化生产。
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| 关 键 词： | 2-巯基-5-甲氧基-1H-苯并咪唑 奥美拉唑 中间体 合成 |
| 文章编号： | 1006-8783(2006)01-0039-02 |
| 收稿时间： | 08 15 2005 12:00AM |
| 修稿时间： | 11 23 2005 12:00AM |
Synthesis of 2-mercapto-5-methoxybenzimidazole |
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| LIU Ya-RU,FENG Xue-song.Synthesis of 2-mercapto-5-methoxybenzimidazole[J].Academic Journal of Guangdong College of Pharmacy,2006,22(1):39-40. |
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| Authors: | LIU Ya-RU FENG Xue-song |
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| Institution: | School of Pharmacy, China Medical University, Shenyang l lO001, China |
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| Abstract: | 2-mercapto-5-methoxybenzimidazole,a key intermediate for the synthesis of omeperazole,was synthesized in 80% yield over two steps.Commercially available 2nitro-4-methoxyaniline was used as starting material and converted via reduction with zinc dust and cyclization with potassium ethyl xanthate into the title compound,suggesting that this procedure is suitable for industrial production. |
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| Keywords: | 2-mercapo-5-methoxybenzimidazole omeperazole intermediate synthesis |
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