甜梦胶囊治疗失眠症期间皮肤交感反应和事件相关电位P300动态研究

目的 :了解甜梦胶囊治疗失眠症患者期间听觉事件相关电位P30 0和皮肤交感反应 (SSR)的改变情况。方法 :选取符合失眠症诊断标准患者 30例 ,年龄相对应的健康志愿者 30例作对照组。失眠症组给予甜梦胶囊 ,分别在服药 4周和 8周治疗后进行P300和SSR检测 ,比较药物治疗前后的P300和SSR的变化及与匹兹堡睡眠质量指数 (PSQI)的关系。结果 :失眠症患者P300的潜伏期延长、波幅降低 ,SSR检测潜伏期延长、波幅降低与对照组比较差异具有显著性 (P<0.01)。与治疗前相比 ,P300仅在8周时Cz点波幅降低有改善 (P<0.05);随着症状和PSQI分数的改善 ,SSR潜伏期、波幅在 4周多数指标有改善 (P<0.05) ,在 8周时更为明显 (P<0.01)。结论 :甜梦胶囊治疗失眠症期间事件相关电位P300有改善 ,而皮肤交感反应则有明显的改善 ,PSQI也有明显改善。

Dynamical examination of auditory event-related potentials P300 and sympathetic skin response in people with insomia of Sweet Dream Capsule therapy

Objective:To observe the change of auditory event-related potentials (P300) and sympathetic skin response (SSR) in people with insomia of Sweet Dream Capsule therapy. Methods: 30 patients meeting criteria for primary insomnia and 30 healthy volunteers with age matching controls were selected for the study. P300 and SSR were measured before treatment of Sweet Dream Capsule and at week 4 , 8 of the therapeutic course. That the change of P300 and SSR before and after treatment and their relations with PSQI were studied. Result: Compared with those of normal controls, both P300 latency and SSR latency were prolonged while amplitude was decreased in patients with insomnia(P<0.01). P300 amplitude was increased significantly at central (Cz) electrode sites only at week 8 when compared with amplitude before treatment (P<0.05).With improvement of symptom and PSQI scores, latency and amplitude of SSR were improved at week 4 and week 8 (P<0.05 and P<0.01). Conclution: P300 has a some improvement in people with insomia of Sweet Dream Capsule therapy while SSR improves significantly, and PSQI scores are ameliorated too.