首页 | 本学科首页   官方微博 | 高级检索  
     

防治母儿血型不合的抗溶冲剂的急性毒性试验及致畸敏感期毒性试验
引用本文:杜惠兰,刘风然,秦满,张俊芬. 防治母儿血型不合的抗溶冲剂的急性毒性试验及致畸敏感期毒性试验[J]. 河北中医, 2006, 28(2): 142-143
作者姓名:杜惠兰  刘风然  秦满  张俊芬
作者单位:河北医科大学中西医结合学院妇产科教研室,石家庄,050091;河北医科大学基础课教学部,石家庄,050011;河北医科大学中医学院门诊部,石家庄,050091
基金项目:河北省中医药管理局科研项目
摘    要:目的研究用于防治母儿血型不合的抗溶冲剂的用药安全性问题。方法对抗溶冲剂进行了小鼠急性毒性试验,经预试实验无法测出其小鼠灌胃给药的LD50,故进行了小鼠灌胃该药,无明显毒性反应,最大耐受量的测定;应用Wistar大鼠对抗溶冲剂进行了致畸敏感期毒性实验。结果①小鼠灌胃给药最大耐受量为492g生药kg,相当于人临床用量的240倍,无明显毒性反应;②该药对大鼠生殖能力、胎鼠生长发育(外观、内脏、骨骼)均无不良影响。结论抗溶冲剂毒性很低,未发现胚胎毒性和致畸性,可用于孕期。

关 键 词:抗溶冲剂  母儿血型不合  急性毒性试验  致畸敏感期毒性试验
文章编号:1002-2619(2006)02-142-02
收稿时间:2005-06-29
修稿时间:2005-06-29

Experimental observation of Kangrongchongji on acute toxicity test and the toxic influence on the fetus malformation sensitiveity state
DU Huilan, LIU Fengran, QIN Man et al. Experimental observation of Kangrongchongji on acute toxicity test and the toxic influence on the fetus malformation sensitiveity state[J]. Hebei Journal of Traditional Chinese Medicine, 2006, 28(2): 142-143
Authors:DU Huilan   LIU Fengran   QIN Man et al
Affiliation:Department of obstetrics and gynecology, TCM Combined with Western Medicine College, Hebei Medical University, Shijiazhuang 050091
Abstract:Objective To observe the safety of Kangrongchongji on preventing the disorder of incompatable blood group between mother and fetus. Methods 20 mice , half male and half female,were fed three times continusly with Kangrongchongji solution after 12 hour's fast. Each feeding interval was five hours and the dosage was 0.4 mg/10 g.The fur color, weitght,appetite,bowel movement, activity mental state were observed after seven days feeding.? Wstar pregnant rats were randomly divied into nomal group, small dosage Kangrongchongji group, great dosage Kangrongchongji group and Vitamin AD group. Each pregnant rat was fed in the seventh day of pregnant and fed for ten days continuosly. In the ninteen day of pregnant, the whole pregnant rats were killed. The amount of fetus rat, the apperence, skeleton and viscera of the fetus rats were observed. Results The fur color, weitght,appetite,bowel movement, activity mental state were normal and no dead experimental mouce was observed.Compared with normal group,there were no significant difference of fetus rats in the small and great dosage Kangrongchongji groups in length, body weitht and plaenta weight(P>0.05).There were no malformal fetus rat in Kangrongchongji group and the skeleton was normal in the whole groups. Conclusions Kangrongchongji has low toxicity without malfromation effection.
Keywords:Kangrongchongji  
本文献已被 CNKI 维普 万方数据 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号