| 肥胖与骨质疏松 |
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| 引用本文： | 张宝伟,雷涛. 肥胖与骨质疏松[J]. 国外医学:内分泌学分册, 2010, 0(4): 242-244 |
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| 作者姓名： | 张宝伟 雷涛 |
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| 作者单位： | 上海同济大学医学院附属同济医院内分泌科,200065 |
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| 摘 要： | 肥胖和骨质疏松是两种密切相关的疾病,成骨细胞和脂肪细胞由骨髓间充质干细胞分化而来,脂肪组织可通过分泌细胞因子影响间充质细胞的分化.肥胖者体内胰源性激素及雌激素水平升高,与瘦素、脂联素、白细胞介索等脂肪细胞因子一起共同组成复杂的网络,影响骨重构.此外,肥胖和骨质疏松还有着共同的基因学基础.对肥胖与骨质疏松关系的研究对骨质疏松的预防有重要意义.
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| 关 键 词： | 肥胖 骨质疏松 脂肪细胞因子 雌激素 胰岛素 |
Obesity and osteoporosis |
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| ZHANG Bao-wei,LEI Tao. Obesity and osteoporosis[J]. Foreign Medical Sciences(Section of Endocrinology), 2010, 0(4): 242-244 |
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| Authors: | ZHANG Bao-wei LEI Tao |
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| Affiliation: | (Department of Endocrinology,Tongji Hospital,Tongji University School of Medicine, Shanghai 200065, China) |
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| Abstract: | There is a close relationship between obesity and osteoporosis.The adipocytes and osteo-blasts are all differentiated from the mesenchymal stem cells（MSCs）. The adipose tissue can change the differentiation of the MSCs by secreting adipocytokines. The estrogen, insulin, leptin, adiponectin and inflammatory factors also have different impacts on bone remodeling. At the same time, there are some common genetics between obesity and osteoporosis. The researches on the relationship between obesity and osteoporosis have great significance on the prevention of osteoporosis. |
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| Keywords: | Obesity Osteoporosis Adipocytokine Estrogen Insulin |
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