Serum 25-hydroxyvitamin D levels and activities of daily living in noninstitutionalized elderly Japanese requiring care |
| |
Authors: | Kazutoshi Nakamura Tomoko Nishiwaki Kimiko Ueno Masaharu Yamamoto |
| |
Institution: | (1) Department of Community Preventive Medicine, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Niigata 951-8510, Japan;(2) Department of Nursing, School of Health Sciences, Niigata University, Niigata, Japan |
| |
Abstract: | To date, no study has investigated the nutritional status of vitamin D in frail elderly people living at home. The purposes
of this study were to assess serum 25-hydroxyvitamin D (25OH]D) levels and associated factors in noninstitutionalized elderly
people who had various levels of physical disability, and to propose an adequate vitamin D nutritional status for the elderly
by interpreting the serum 25(OH)D levels in relation to serum parathyroid hormone (PTH) levels in this population. Health
examinations were conducted in the winter and summer of 2003. The subjects were 143 elderly people in the winter, and 120
elderly people in the summer, who all used the long-term care insurance system at home. Serum 25(OH)D concentrations were
determined with a chemiluminescence protein-binding assay, and serum intact PTH concentrations were determined with an immunoradiometric
assay. The subjects' disease histories and lifestyle information were obtained through an interview. Activities of daily living
(ADL) levels were evaluated using the Barthel index, and grip strength was measured with a digital hand dynamometer. Average
serum 25(OH)D levels in the winter and summer were 54.2 nmol/l (SD 29.0) and 53.3 nmol/l (SD 32.3), respectively, and intact
PTH concentrations in the winter and summer were 4.2 pmol/l (SD 1.8) and 4.3 pmol/l (SD 1.8), respectively. The proportion
of people who had a low 25(OH)D (<30 nmol/l) and high intact PTH levels (>6.9 pmol/l) were 15%–20% and 8%, respectively. Significant
predictors of low serum 25(OH)D concentrations were low ADL levels, female sex, and low fish consumption in both seasons.
Serum 25(OH)D concentrations of less than 50 nmol/l were associated with elevated serum intact PTH concentrations. In conclusion,
elderly people requiring care at home are at high risk of hypovitaminosis D, and their low serum 25(OH)D levels are mainly
associated with low ADL levels. In addition, maintenance of serum 25(OH)D concentrations above 50 nmol/l may prevent hypovitaminosis
D-induced hyperparathyroidism. |
| |
Keywords: | Activities of daily living (ADL) Elderly 25-Hydroxyvitamin D (25[OH]D) Japanese Parathyroid hormone Seasonal difference |
本文献已被 PubMed SpringerLink 等数据库收录! |
|