| 内毒素预处理对大鼠前脑缺血再灌注后海马神经元保护效应的研究 |
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| 引用本文： | 向强,杨娟,文亮,刘明华. 内毒素预处理对大鼠前脑缺血再灌注后海马神经元保护效应的研究[J]. 第三军医大学学报, 2003, 25(19): 1762-1764 |
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| 作者姓名： | 向强 杨娟 文亮 刘明华 |
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| 作者单位： | 1. 第三军医大学附属西南医院ICU,重庆,400038
2. 第三军医大学附属西南医院眼科,重庆,400038 |
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| 摘 要： | 目的 探讨内毒素预处理对大鼠前脑缺血再灌注后海马神经元的保护效应及其可能机制。方法 采用大鼠前脑缺血再灌注模型，动态观察内毒素预处理对脑组织SOD、GSH-PX、MDA活性的影响及海马CA1区神经元计数的变化。结果 内毒素预处理后脑组织内生性SOD、GSH-PX活性显著增高，MDA活性降低，海马CA1区神经元计数下降幅度减少。结论 ①内毒素预处理对前脑缺血再灌注后海马神经元的损伤有明显保护作用；②其机制可能与增强中枢神经系统内生性抗过氧化物酶类的活性有关。
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| 关 键 词： | 脑缺血 再灌注 预处理 内毒素 |
| 文章编号： | 1000-5404(2003)19-1762-03 |
| 修稿时间： | 2003-01-13 |
Experimental study of the protective effect of endotoxin pretreatment on hippocampal neurons in rat forebrain following ischemia-reperfusion |
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| XIANG Qiang,YANG Jun,WEN Liang,LIU Ming hua. Experimental study of the protective effect of endotoxin pretreatment on hippocampal neurons in rat forebrain following ischemia-reperfusion[J]. Acta Academiae Medicinae Militaris Tertiae, 2003, 25(19): 1762-1764 |
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| Authors: | XIANG Qiang YANG Jun WEN Liang LIU Ming hua |
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| Abstract: | Objective To investigate the protective effect of endotoxin pretreatment on hippocampal neurons in rat forebrain following ischemia reperfusion and its possible mechanism. Methods Rat forebrain ischemia reperfusion model was used. The effects of endotoxin pretreatment on the changes of superoxide dismutase (SOD), glutathione peroxidase (GSH PX) and malondialdehyde (MDA) activities and the neuron count in CA1 region were observed. Results Pretreament with endotoxin before cerebral ischemia enhanced the activities of SOD and GSH PX but decreased MDA level and the number of ischemic neurons in CA1 region. Conclusion Endotoxin pretreatment can protect the neurons in rat forebrain against ischemia reperfusion injury. The mechanism may be associated with the enhancement of endogenous antioxidant activity in central nervous system. |
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| Keywords: | cerebral ischemia reperfusion pretreatment endotoxin |
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