Impaired insulin-induced site-specific phosphorylation of TBC1 domain family, member 4 (TBC1D4) in skeletal muscle of type 2 diabetes patients is restored by endurance exercise-training |
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| Authors: | Vind B F Pehmøller C Treebak J T Birk J B Hey-Mogensen M Beck-Nielsen H Zierath J R Wojtaszewski J F P Højlund K |
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| Affiliation: | (1) Diabetes Research Center, Department of Endocrinology, Odense University Hospital, Kl?verv?nget 6, 4, 5000 Odense, Denmark;(2) Molecular Physiology Group, Copenhagen Muscle Research Centre, Department of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark;(3) Institute of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark;(4) Section for Integrative Physiology, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; |
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| Abstract: | Aims/hypothesis Insulin-mediated glucose disposal rates (R d) are reduced in type 2 diabetic patients, a process in which intrinsic signalling defects are thought to be involved. Phosphorylation of TBC1 domain family, member 4 (TBC1D4) is at present the most distal insulin receptor signalling event linked to glucose transport. In this study, we examined insulin action on site-specific phosphorylation of TBC1D4 and the effect of exercise training on insulin action and signalling to TBC1D4 in skeletal muscle from type 2 diabetic patients. |
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