神经行为发育监测及早期干预对高危儿智能发育影响的研究

目的 探讨神经行为发育监测及早期干预对高危儿智能发育的影响,提高高危儿的生存质量.方法 将46例高危儿随机分为干预组和对照组,同时选取20例正常对照组进行随访观察.对干预组的高危儿定期进行神经行为发育监测和早期干预.各组均在3月、6月和1岁时用Gesell婴幼儿发育量表进行发育商的测评.结果 ① 3月时高危干预组和高危对照组5个能区的发育商（developmental quotient,DQ）均低于正常对照组 （P＜0.01）;高危干预组和高危对照组比较,各能区的DQ无差异（P＞0.05）.② 6月时高危干预组各能区的DQ均高于高危对照组,差异有统计学意义（P＜0.01和P＜0.05）;高危干预组和正常对照组4个能区的DQ无差异（P＞0.05）.③ 1岁时高危干预组各能区的DQ均明显高于高危对照组,差异有高度统计学意义（P＜0.01）;高危干预组与正常对照组比较,各能区的DQ无差异（P＞0.05）.结论 神经行为发育监测及早期干预可以促进高危儿的智能发育,到1岁时能赶上正常儿童,有效减少残障的发生.

Reserch of the impact of neurobehavioral developmental monitoring and early intervention on development of high-risk neonates

Objective To investigate the impact of neurobehavioral developmental monitoring and early intervention on development of high-risk neonates, to improve the quality of life. Methods 46 High-risk neonates were randomly divided into the intervention group and the control group, and the age-matched 20 normal children were selected as normal control group. Regular neurobehavioral development monitoring and early intervention were performed in high-risk intervention group. Every group re- ceived the evaluation of developmental quotient （DQ） by Gesell infant development scale at 3 months, 6 months, and 1 year after birth, respectively. Results （~）At 3 month, the DQs in high-risk intervention group and high-risk control group were significant- ly lower than normal control group （ P 〈 0. 01 ）. There were no significant differences in the DQs between the two groups of high-risk（P 〉 0. 05. ） （~）At 6 month, all the DQs of high-risk intervention group were significantly higher than high-risk control group （ P 〈 0.01 $31 P 〈 0. 05 ）. There were no significant differences in the DQ of four ability regions to people between high-risk intervention group and normal control group （ P 〉 0. 05 ）. （~）At 1 year, the DQs of high-risk intervention group were extremely higher than high-risk control group （ P 〈 0.01 ）. There were no significant differences in the DQs between high-risk intervention group and normal control group （ P 〉 0.05 ）. Conclusion Neurobehavioral developmental monitoring and early intervention can promote the high-risk neonates＇ neurobehavioral development, catch up the normal children at 1 year after birth, reduce the inci- dence of disability.