TACE联合3-DCRT及热疗治疗中晚期原发性肝癌的疗效观察 |
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引用本文: | 任丽,李迎春,谭新劲,叶奕兰,刘云,郑伟. TACE联合3-DCRT及热疗治疗中晚期原发性肝癌的疗效观察[J]. 四川医学, 2013, 0(10): 1587-1589 |
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作者姓名: | 任丽 李迎春 谭新劲 叶奕兰 刘云 郑伟 |
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作者单位: | 解放军第452医院放疗科医学影像科,四川成都610021 |
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摘 要: | 目的 探讨肝动脉灌注栓塞化疗(TACE)联合三维适形放疗(3-DCRT)及热疗治疗中晚期原发性肝癌的疗效及不良反应.方法 对54例肝癌患者先行TACE治疗1~2次,一次TACE后行4次热疗;4周后行3-DCRT治疗,同时行热疗.放疗分割剂量2.6~3.0Gy/次,总剂量46~60Gy,热疗1周2次,间隔72h.观察近期疗效及不良反应.结果 54例肝癌患者治疗后,完全缓解(CR)13例(24.1%);部分缓解(PR)35例(64.8%);稳定(NC)4例(7.4%);进展(PD)2例(3.7%);总有效率(CR+PR)为88.9%(48/54).治疗后AFP均有不同程度的下降.1、2、3年生存率分别为77.8%、59.3%、40.7%.结论 TACE联合3-DCRT及热疗治疗中晚期原发性肝癌具有较好的疗效,不良反应无明显增加.
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关 键 词: | 原发性肝癌 肝动脉灌注栓塞化疗 三维适形放疗 热疗 |
The effect of TACE combined with 3-DCRT and hyperthermia on patients with advanced primary hepatic carcinoma |
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Affiliation: | REN Li,LI Ying-chun, TAN Xin-jing ,et al.( The 452 PLA Hospital, Chengdu,Sichuan 610021 ,China) |
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Abstract: | Objective To evaluate the efficacy and side effects of transcatheter arterial chemoembolization(TACE) com- bined with three-dimensional conformal radiotherapy (3-DCRT) and hyperthermia on advanced primary hepatic carcinoma(PHC). Methods A total of 54 patients were treated with TACE, followed by hyperthermia, and then 3-DCRT. All patients underwent TA- CE 1 - 2course and 3-DCRT of 46 - 60Gy were performed after 4 weeks interval of TACE. Results There were 13 cases with CR (24. 1% ) ,35 cases with PR(64. 8% ) ,4 cases with NC(7.4% )and 2 cases with PD(3.7% ) in 54 cases,the total effective rate ( CR + PR) was 88.9%. The 1,2,3year survival rates were 77.8% , 59. 3% ,40. 7%. Conclusions TACE combined with 3- DCRT and hyperthermia is more effective for advanced PHC ,without increasing side effects. |
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Keywords: | primary hepatic carcinoma (PHC) transcatheter arterial chemoembolization (TACE) three-dimensional con-formal radiotherapy (3-DCRT) hyperthermia |
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