The relationship between bronchial histamine reactivity and atopic status |
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Authors: | D H BRYANT M W BURNS |
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Institution: | Garvan Institute of Medical Research, St Vincent's Hospital, Darlinghurst, N.S.W., Australia |
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Abstract: | It has been proposed that increased production of IgE, a feature of atopy, is a cause of the non-specific bronchial hyper-reactivity that is characteristic of asthma. This hypothesis was examined by selecting groups of subjects with asthma or rhinitis and a group of healthy control subjects and studying the relationship between their bronchial histamine reactivity and their atopic status. In none of the groups tested was there a significant association between the degree of bronchial histamine reactivity and either the serum level of total IgE or the number of extracts of aero-allergens giving positive prick test reactions. |
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