电针配合神经生长因子对脑缺血大鼠学习记忆能力的影响 |
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引用本文: | 林咸明,谭克平,张爱军,何丽华.电针配合神经生长因子对脑缺血大鼠学习记忆能力的影响[J].中华物理医学杂志,2006,31(1):377-379. |
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作者姓名: | 林咸明 谭克平 张爱军 何丽华 |
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作者单位: | 浙江中医药大学第三临床医学院,杭州,310053; |
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基金项目: | 国家中医药管理局资助项目浙江省中医药管理局资助项目浙江省高校"重中之重学科"(针灸推拿学)开放基金资助项目 |
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摘 要: | Objective To observe the effect of nerve growth factor(NGF)and electro-acupuncture(EA) on learning and memory in rats with cerebral ischemia.Methods An experimental model of cerebral ischemiareperfusion was established in 40 rats,who were then randomly divided into a model group,a sham operated group,a NGF group,an acupuncture group and a NGF plus acupuncture group.Three weeks were allowed for the recovery of the blood-brain barrier lesion caused by ischemia-reperfusion before intravenous injection of NGF(10μg/kg,once daily for 15 days)via the vena caudalis.In the two acupuncture groups,this was administered in combination with EA at the Baihui(DU20)and Yamen(DU15)acupoints(frequency 100 Hz,2 mA,20 min/time,once daily for 15 days).Morris' water maze test was used to assess any changes in spatial learning and memory abilities.Results The ischemic rats showed significant learning and memory disorders compared with the sham-operated group.In the NGF group,the rats' learning and memory abilities did not impmve significantly compared with the model group and the EA group.Significantly better learning was observed in the NGF+EA group compared with the model group,the EA group and the NGF group.Conclusion NGF combined with EA can improve the learning and memory abilities of rats with learning and memory dysfunction caused by cerebral ischemia-repedusion.
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关 键 词: | 电针 神经生长因子 学习 记忆 百会穴 哑门穴 |
The effect of electro-acupuncture in combination with nerve growth factor on learning and memory in rats with cerebral ischemia |
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Abstract: | |
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Keywords: | Electro-acupunctureNerve growth factorLearningMemoryBaihui acupointYamen acupoint |
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