小儿原发性肾病综合征患者血凝状态测定

目的 :探讨小儿原发性肾病综合征患者的血凝状态。方法 :对 36例单纯性肾病 ,2 0例肾炎性肾病和 45例健康对照组的血凝状态进行检测。利用日本E 2锥板粘度计检测血液粘度 ;利用毛细玻璃管粘度计检测血浆粘度 ;利用玻璃珠柱法检测血小板粘附功能 ;利用比浊法测定血小板聚集功能 ;利用放免法测定血浆血栓烷B2 (TXB2 ) ,6 酮 前列腺素F1α(6 Keto PGF1a)。结果 :单纯性肾病和肾炎性肾病与对照组比较 ,3.8s- 1 ,9.6s- 1 ,19.2s- 1 ,38.3s- 1 ,76 .8s- 1 ,192s- 1 和 382s- 1 切变率下的血液粘度、血浆比粘度和红细胞压积明显增加 ;红细胞沉降率明显加快 ;血小板计数明显增多 ,血小板粘附率、ADP或肾上腺素诱导的血小板最大聚集率明显增高 ;血浆TXB2 ,TXB2 6 Keto PGF1a明显增高 ,P均 <0 .0 5。结论 :原发性肾病综合征患儿存在血液粘滞性增加、血小板数目增多及功能增强、血TXA2 PGI2 平衡失调 ,存在高凝状态。

Study of coagulability in children with idiopathic nephrotic syndrome

To research the hypercoagulability in children with nephroficsyndrome (NS).Methods:A total of 36 casesof sknple nephrosis and 20 cases of nephrosis were taken as experimental gxoup with 45 healthy subjects as contxol. The adhering and aggregating functions of platelets were detected by the glass bead viscosimeter and turbidimetry methods, respectively; the bloodconcentrations of TXB2 and 6-Keto-PGF1a were determined by radioimmunology. Results: Compared with control group, the blood/plasma viscosity, packed cell volume and ESR under different shear rates elevated significantly ( P < 0.05); platelet count, plateletviscosity rate, and the levels of TXB2,6-Keto-PGF1α and TXB2/6-Keto-PGF1a in plasma also increased significantly (P < 0.05).Conclusion:The results indicate that the children with NS have hyper-coagulability.