| 大鼠脑缺血再灌注后腺病毒表达GluR羧基肽段对脑组织JNK磷酸化的影响 |
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| 引用本文： | 孙亚峰,宋远见,周峰,刘红芝,裴冬生. 大鼠脑缺血再灌注后腺病毒表达GluR羧基肽段对脑组织JNK磷酸化的影响[J]. 山东医药, 2009, 49(21): 1-2 |
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| 作者姓名： | 孙亚峰 宋远见 周峰 刘红芝 裴冬生 |
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| 作者单位： | 1. 徐州医学院基础学院,江苏徐州,221004
2. 徐州医学院肿瘤生物治疗重点实验室 |
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| 基金项目： | 江苏省自然科学基金，国家自然科学基金 |
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| 摘 要： | 目的探讨大鼠脑缺血再灌注（IR）后腺病毒表达谷氨酸受体（GluR）羧基肽段对海马CA1区神经元的保护作用和JNK磷酸化的影响。方法将SD大鼠随机分为假手术组、IR对照组、表达病毒组、非表达病毒组及溶剂组。采用焦油紫染色、免疫印迹检测大鼠IR后海马神经元损伤和脑组织JNK的磷酸化情况。结果与IR对照组、非表达病毒组及溶剂组比较，表达病毒组海马CA1区神经元损伤明显减轻，脑组织JNK磷酸化程度明显降低（P均〈0．05）。结论腺病毒表达GluR羧基肽段可能通过降低脑组织JNK磷酸化程度对海马CA1区神经元起保护作用。
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| 关 键 词： | 再灌注损伤 腺病毒 谷氨酸受体羧基肽段 JNK |
Effect of adenovirus expressing glutamic acid receptor c-terminal peptide on phosphorylation of JNK in rat during brain ischemia and reperfusion |
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| SUN Ya-feng,SONG Yuan-jian,ZHOU Feng,LIU Hong-zhi,PEI Dong-sheng. Effect of adenovirus expressing glutamic acid receptor c-terminal peptide on phosphorylation of JNK in rat during brain ischemia and reperfusion[J]. Shandong Medical Journal, 2009, 49(21): 1-2 |
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| Authors: | SUN Ya-feng SONG Yuan-jian ZHOU Feng LIU Hong-zhi PEI Dong-sheng |
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| Affiliation: | SUN Ya-feng1,SONG Yuan-jian,ZHOU Feng,LIU Hong-zhi,PEI Dong-sheng(1 Basic Medical Institute,Xuzhou Medical College,Xuzhou 221004,P.R.China) |
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| Abstract: | Objective To investigate the neuroprotection of adenovirus expressing glutamic acid receptor c-terminal peptide paragraph and effect on phosphorylation of JNK in rat hippocampal CA1 region after brain ischemia and reperfusion.Methods SD rats were randomly divided into 5 groups: sham-operated;cerebral ischemia and reperfusion;cerebral ischemia and reperfusion+expressing virus treatment;cerebral ischemia and reperfusion+ no-expressing virus treatment and reperfusion+solvent.Brain injury in hippocampus of rats... |
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| Keywords: | JNK |
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