医院感染革兰阴性菌的耐药性变迁

目的调查我院3年来医院感染革兰阴性分离菌及其药物敏感性,为临床合理应用抗生素提供参考.方法用纸片扩散法进行体外药敏试验,WHONET4软件进行统计分析.结果 3年间居前3位的革兰阴性菌分别为铜绿假单胞菌、大肠埃希菌和肺炎克雷伯菌;对其常用抗生素的敏感性分析发现,3年间大多数抗生素的敏感性均有较大幅度下降, 同时产β-内酰胺酶(ESBLs)菌逐年增多.结论应注意合理使用抗生素并加强对细菌耐药性的全面监测.

Vicissitudes of Drug Resistance of G- Isolates in Nosocomial Infection

OBJECTIVETo determine the antimicrobial susceptibility of G- isolates during the past 3 years to provide basis for reasonable use of antibiotics. METHODS K-B disc agar diffusion method was adopted to detect drug susceptibility in vitro and WHONET4 software was applied to analyze the data. RESULTSThe first three G- bacteria with highest number were Pseudomonas aeruginosa, Escherichia coli and Klebsiella pneumoniae respectively. The susceptibility of the most common-used antibiotics decreased greatly. In the meanwhile, ESBLs-producing strains were increasing year by year. CONCLUSIONSAntibiotics should be used reasonably and all-round supervision of drug resistance should also be strengthened.