Fatal varicella hepatitis in an asthmatic adult after short-term corticosteroid treatment |
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| Authors: | Hyvernat Hervé Roger Pierre-Marie Pereira Cécile Saint-Paul Marie Christine Vandenbos Frédéric Bernardin Gilles |
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| Affiliation: | 1. ASELSAN, Naval Systems Program Directorate, Ankara 06172, Turkey;2. Department of Industrial Engineering, Middle East Technical University, Ankara 06800, Turkey;3. Department of Industrial Engineering, Yaşar University, İzmir, Turkey;1. Faculty of Sciences, National Autonomous University of Mexico, Mexico City, Mexico;2. Mathematical Sciences, Brunel University, Uxbridge UB8 3PH, UK and JB Consultants, Morden, UK;1. School of Mathematics and Statistics, University of Sydney, Sydney, NSW 2006, Australia;2. Centre for Applied Financial Studies, City West Campus, University of South Australia, 37–44 North Tce, Adelaide, SA 5001, Australia;3. School of Business, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA 6027, Australia |
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| Abstract: | A 28-year-old male patient, treated with prednisone for bronchitis with sibilant rales, developed fever with abdominal pain and generalized vesicular rash after coming in contact with varicella-infected children. He was hospitalized after having a seizure. Laboratory values revealed hepatitis and rapidly fulminant hepatic insufficiency with disseminated intravascular coagulation. Despite acyclovir treatment, the patient died 4 days after admission. Clinical presentation could evoke a Reye's syndrome, but liver biopsy showed massive coagulative necrosis. This report demonstrates the increased risk of complicated varicella associated with the use of corticosteroids, even for a short period of time. |
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