Seronegative spondyloarthropathies and HLA antigens in a Mestizo population |
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Authors: | GLORIA E. PÉ REZ-ROJAS,HERNÁ NDO PAUL-MOYA,NICOLÁ S E. BIANCO,ISAAC ABADÍ |
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Affiliation: | Clinical Immunology National Center, SAS-UCV and the WHO/PAHO Collaborative Center in Clinical Immunology (CECOIC).;The Rheumatic Diseases National Center, Venezuela. |
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Abstract: | HLA-A and -B antigens incidence were investigated in 100 cases of Seronegative Spondyloarthropathies and in 303 control individuals of a Venezuelan Mestizo population. Significative increased incidence of B27 was found among 69% of patients with ankylosing spondylitis and 68% with Reiter syndrome being the incidence in the control group of 2.9%. The B27 negative patients showed 40.4% positivity for Bw35, with spondylitic lesion in 12 out of 17 cases. Our results question the applicability of B27 as diagnostic criteria in the Mestizo patients bearers of a Seronegative Spondyloarthropathy and suggest the need to investigate further the role of antigens of the B locus in the pathophysiology of these clinical entities. |
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