|
|||||
|
|
| 葡萄籽原花青素对环磷酰胺诱发小鼠骨髓多染红细胞微核形成的抑制作用及其机理探讨 | |
| 引用本文： | 孙志广,赵万洲,陆茵,唐玲芳,张珍玲,阮君山,闫新琦,薛普凤,张世玮.葡萄籽原花青素对环磷酰胺诱发小鼠骨髓多染红细胞微核形成的抑制作用及其机理探讨[J].时珍国医国药,2000,11(5):386-387. |
| 作者姓名： | 孙志广 赵万洲 陆茵 唐玲芳 张珍玲 阮君山 闫新琦 薛普凤 张世玮 |
| 作者单位： | 1. 江苏省中医院,江苏,南京,210029 2. 南京中医药大学,江苏南京,210029 3. 南京医科大学,江苏,南京,210029 |
| 基金项目： | 中国博士后基金资助项目! No.1997·7 |
| 摘 要： | 通过微核试验和小鼠肝组织中谷胱甘肽－Ｓ－转移酶（ＧＳＴ）活性、还原型谷胱甘肽（ＧＳＨ）含量的测定，在哺乳动物整体水平，从遗传学和生化毒理学角度进上步研究了原花青素（ＰＶ２０００）的抗诱变作用及其。结果发现，原花青素对环磷酰胺（ＣＰＡ）诱发的小鼠骨髓多染红细胞（ＰＣＥｓ）微核细胞率有较强抑制作用，并能提高肝脏ＧＳＴ活性，升高ＧＳＨ含量。说明原花青素对化学诱变剂引起的染色体断裂有一定保护作用。其作用机 |
| 关 键 词： | 原花青素 中药 葡萄籽 抗诱发 微核实验 |
| 修稿时间： | 1999-01-10 |
The Inhibitory Eeffect and its Mechanism Procyanidins from Vitis vinifera Seed on Cyclophosphamide Inducing Micronuclear Formation |
|
| SUN Zhi-guang,ZNAO Wan-zhou,LU Yin,TANG Ling-fang,ZNANG Zhen-ling,RUAN Jun-shan,YAN Xin-qi,XUE Pu-feng,ZNANG Shi-wei.The Inhibitory Eeffect and its Mechanism Procyanidins from Vitis vinifera Seed on Cyclophosphamide Inducing Micronuclear Formation[J].Lishizhen Medicine and Materia Medica Research,2000,11(5):386-387. | |
| Authors: | SUN Zhi-guang ZNAO Wan-zhou LU Yin TANG Ling-fang ZNANG Zhen-ling RUAN Jun-shan YAN Xin-qi XUE Pu-feng ZNANG Shi-wei |
| Abstract: | The antimutagenic effect of procyanidins(PV 2000) on cyclophosphamide(CPA) inducing micronucleus of PCEs in mice bone marrow and the effect on glutathione S transferase (GST) activity,glutathione (GSH) level in the liver of mice were investigated. The result showed that the CPA induced micronucleus rate were inhibited from 18.06% to 48.69%. The GST activity and GSH level increased obviously. The experiments suggest that procyanidins have the effect of inhibiting mutagenesis and is probably related to improving the detoxifying function of the liver. |
| Keywords: | Procyanidins Vitis vinifera Antimutagenesis Micronucleus test Gluathione S transferase (GST) Glutathione (GSH) |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |