Relationship between urinary excretion of modified nucleosides and rheumatoid arthritis process |
| |
Authors: | Tebib JG; Reynaud C; Cedoz JP; Letroublon MC; Niveleau A |
| |
Institution: | CHLS, Pierre Benite, France. |
| |
Abstract: | The levels of the five methylated nucleosides pseudouridine (psi-Urd),
1-methyladenosine (1-MeAdo), 4 acetylcytidine (4-AcCyd), 1 methylinosine
(1-Melno) and 7 methylguanosine (7-MeGuo) resulting from RNA degradation
were examined in the urine of rheumatoid arthritis (RA) patients. Of these
five, 1-MeAdo and psi-Urd were correlated with the active phase of the
disease, while two others (4-AcCyd and 1-Melno), which require further
evaluation, appeared to be linked to the prognosis of the disease. As RNA
turnover is closely associated with cell proliferation, including that of
lymphocytes in RA, there may be a hitherto unsuspected benefit in measuring
1-MeAdo and psi-Urd as biochemical markers of RA disease activity.
|
| |
Keywords: | |
本文献已被 Oxford 等数据库收录! |
|