| EFFECT OF SUPEROXIDE DISMUTASE AND DIETHYLDITHICARBAMATE ON THE INDUCTION OF SQUAMOUS CELL CARCINOMA OF LUNG WITHMETHYL CHOLA |
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| 引用本文： | 刘铭球,喻伦银,舒清波,吴天鹏,田鸿生,夏东,刁路明,邹祖玉,刘晓翌,黄春妮,陈显皋,张永幸,周洁,唐华. EFFECT OF SUPEROXIDE DISMUTASE AND DIETHYLDITHICARBAMATE ON THE INDUCTION OF SQUAMOUS CELL CARCINOMA OF LUNG WITHMETHYL CHOLA[J]. 中国癌症研究, 1995, 7(4): 262-266. DOI: 10.1007/BF02672789 |
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| 作者姓名： | 刘铭球 喻伦银 舒清波 吴天鹏 田鸿生 夏东 刁路明 邹祖玉 刘晓翌 黄春妮 陈显皋 张永幸 周洁 唐华 |
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| 作者单位： | Liu Mingqiu; Yu Lunyin; Shu Qingbo; Wu Tianpeng; Tian Hongsheng; Xia Dong; Diao Luming; Zou Zuyu; Liu Xiaoyi; Huang Chunni; Chen Xiangao; Zhang Yongxing Zhou Jie Tang Hua(Department of pathology，Hubei Medical University，Wuhan 430071 |
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| 摘 要： | 刘铭球，喻伦银，舒清波，吴天鹏，田鸿生，夏东，刁路明，邹祖玉，刘晓翌，黄春妮，陈显皋，张永幸，周洁，唐华ＥＦＦＥＣＴＯＦＳＵＰＥＲＯＸＩＤＥＤＩＳＭＵＴＡＳＥＡＮＤＤＩＥＴＨＹＬＤＩＴＨＩＣＡＲＢＡＭＡＴＥＯＮＴＨＥＩＮＤＵＣＴＩＯＮＯＦＳＱＵＡＭＯ...
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| 修稿时间： | 1995-06-22 |
Effect of superoxide dismutase and diethyldi-thicarbamate on the induction of squamous cell carcinoma of lung withmethyl-cholanthren in rats |
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| Liu Mingqiu,Yu Lunyin,Shu Qingbo,Wu Tianpeng,Tian Hongsheng,Xia Dong,Diao Luming,Zou Zuyu,Liu Xiaoyi,Huang Chunni,Chen Xiangao,Zhang Yongxing,Zhou Jie,Tang Hua. Effect of superoxide dismutase and diethyldi-thicarbamate on the induction of squamous cell carcinoma of lung withmethyl-cholanthren in rats[J]. Chinese Journal of Cancer Research, 1995, 7(4): 262-266. DOI: 10.1007/BF02672789 |
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| Authors: | Liu Mingqiu Yu Lunyin Shu Qingbo Wu Tianpeng Tian Hongsheng Xia Dong Diao Luming Zou Zuyu Liu Xiaoyi Huang Chunni Chen Xiangao Zhang Yongxing Zhou Jie Tang Hua |
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| Affiliation: | (1) Department of pathology, Hubei Medical University, 430071 Wuhan;(2) Department of Urology, 1st Affiliated Hospital, Hubei medical University, 430060 Wuhan;(3) The 3rd Hospital of Wuchang District, 432600 Wuhan |
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| Abstract: | The 3rd Hospital of Wuchang District ,Wuhan 432600)The squamous cell carcinoma of lung was induced with methylcholanthrene (MCA) in iodized oil in wistar rts- During the development of the cancer, the animals were given superoxide dismutase (SOD) or its inhibitor diethyldio-carhamate (DDC). In DDC group, 3 out of 50 rats developed cancer and 4 developed atypical hyperplasia of hronchial epithelium within 35 to 40 days.In SOD group, no cancer developed in all of the 52 rats.and only one had atypical hyperplasia in the lungs. Only one of 42 control rats had cancer and 2 rats had atypical hyperplasia of bronchial epithelium . The difference in cancer frequency between groups DDC and SOD was significant (P<0.05). The results suggest that there is a synergism between DDC and MCA in the induction of lung cancer, while SOD can inhibit MCA-induced lung cancer development. The mechanism of the effect of SOD and DDC was discussed. |
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| Keywords: | Superoxide dismutase (SOD) Induced lung cancer Squamous cell carcinoma Diethyldithiocarbamate (DDC) Methylcholan-threne (MCA) |
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