杜仲对小鼠胰岛素抵抗干预作用的研究

目的 研究杜仲对小鼠胰岛素抵抗的干预作用.方法 选择雄性小鼠48只,随机分为6组:杜仲低、中、高剂量组、阳性对照组(罗格列酮组)、模型对照组和正常对照组,前5组小鼠在建立胰岛素抵抗模型的同时分别给予相应药物灌胃,1次/天.2周后,禁食12h,测定各组小鼠空腹血糖(FPG),随后尾静脉注射胰岛素,测定5min、15min、30min时各组小鼠的血糖浓度.结果 杜仲高剂量组与模型对照组、空白对照组相比,小鼠血糖下降水平具有显著性差异(P＜0.05),且与阳性对照组比较,小鼠血糖下降速度及水平更快更低(P＜0.05);杜仲中剂量对小鼠胰岛素敏感性亦有一定改善效应(P＜0.05),数据表明15min时血糖下降达较低点,此后几乎能与正常小鼠保持同等水平;杜仲低剂量对胰岛素抵抗小鼠的胰岛素增敏效应不明显,无统计学意义(P＞0.05).结论 杜仲高和中剂量组能显著提高小鼠对胰岛素的敏感性,较好地于预胰岛素抵抗,且高剂量杜仲煎液的胰岛素增敏效应有町能优于罗格列酮.

Research on Eucommia's Intervention in Insulin Resistance in Jimpy Mice

Objective To study Eucommia's intervention on insulin resistance in jimpy mice with hypertension.Methods Choose 48 male jimpy mice,and then randomly divide into 6 groups.They are Eucommia in low,middle and high dose groups,the positive control group(rosiglitazone group),the model group,and the normal control group.For the first five groups of mice,give them appropriate gavage with medicine while establishing the model of insulin resistance,once for each day.After two weeks,give them 12 hour fasting,test mic...