| PCR方法检测微量残留白血病细胞 |
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| 引用本文： | 郭俊明 张庭龙. PCR方法检测微量残留白血病细胞[J]. 赣南医学院学报, 1997, 17(2): 99-101 |
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| 作者姓名： | 郭俊明 张庭龙 |
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| 作者单位： | Guo Junming，et al |
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| 摘 要： | 以Ｎ－ｒａｓ癌基因突变作为急性髓细胞白血病的分子标志，用ＰＣＲ技术研究该病的微量残留白血病细胞。１２例缓解期患者中检测到４例有Ｎ－ｒａｓ癌基因突变，对１０列患者作动态观察发现２例突变一直存在，２例在病程中发生突变。因此，Ｎ－ｒａｓ癌基因突变可用于检测ＭＲＬＣ。
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| 关 键 词： | 白血病 髓细胞性 N－ras癌基因 PCR MRLC |
Detection of Minimal Residual Leukemia Cells by PCR |
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| Guo Junming,et al. Detection of Minimal Residual Leukemia Cells by PCR[J]. Journal of Gannan Medical College, 1997, 17(2): 99-101 |
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| Authors: | Guo Junming et al |
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| Abstract: | he mutation of N-ras oncogene was using as a molecular marker of acute myeloidleukemia and then the minimal residual leukemia cells(MRLC)was studied by PCR.The re-sults were:4 of 12 patients during remissive period had been found mutations;when 10 caseswere observed during whole sick period two of them had been detected mutationscontinuously the ther two patients had been found mutations occured in sick period As a re-sults the mutations of N-ras can be used to detected the MRLC |
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| Keywords: | Leukemia/myeloid N-ras Minimal residual leukemia cells PCR |
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