江苏省苏州市社区老年人群轻度认知功能损害危险因素的Logistic回归分析

目的探讨轻度认知功能损害(MCI)可能的危险因素。方法采用以人群为基础按1∶2的比例进行年龄、性别、文化程度、职业性质相匹配的病例对照研究,病例为调查的人样本群中确诊的MCI患者81例,对照为同人群中符合匹配条件的认知功能正常者162例。用SAS8.2软件进行单因素分析和非条件Logistic回归分析。结果 Logistic回归分析显示,丧偶或离异、经历负性生活事件者患MCI的危险较大,OR值(95%CI)分别为1.770(1.157~3.516)、1.875(1.015~3.464),兴趣爱好与MCI呈负相关,其OR值为0.320(0.173~0.594)。结论离异或丧偶、负性生活事件可增加AD患病的危险性,兴趣爱好可能对MCI具有保护作用。

A logistic regression analysis of risk factors for mild cognitive impairment in urban community of Suzhou

Objective To study the risk factors of mild cognitive impairment in the elderly in urban community of Suzhou.Methods A population based,1∶2 matched case-control study was conducted,including 81 MCI patients from sample population as cases and 162 non-cognitive impairment individuals from the same population matched for age,sex and education as controls.Data was analyzed using univariate analysis and non-condition logistic regression analysis with SAS8.0 software.Results In multivariate logistic analysis,divorced or widowed,negative events were shown to be the risk factors for MCI,and OR were 1.770(1.157～3.516),1.875(1.015～3.464).However,individual interesting were negatively correlated with MCI and their ORs were 0.320(0.173～0.594).Conclusion The study demonstrated that widowed and negative events were risk factors for MCI,but individual interesting may be the protection factor.