| PGE1对体外循环术后肺高压及右心功能的影响 |
| |
| 引用本文： | 黄日太,朱洪生,张有荣,吴建军,张谷兰,卢蓉. PGE1对体外循环术后肺高压及右心功能的影响[J]. 上海交通大学学报(医学版), 2000, 20(1): 35-38 |
| |
| 作者姓名： | 黄日太 朱洪生 张有荣 吴建军 张谷兰 卢蓉 |
| |
| 作者单位： | 黄日太（上海第二医科大学仁济医院心胸外科，上海 200001）;朱洪生（上海第二医科大学仁济医院心胸外科，上海 200001）;张有荣（上海第二医科大学仁济医院心胸外科，上海 200001）;吴建军（上海第二医科大学仁济医院心胸外科，上海 200001）;张谷兰（上海第二医科大学仁济医院心胸外科，上海 200001）;卢蓉（上海第二医科大学仁济医院心胸外科，上海 200001） |
| |
| 摘 要： | 目的研究体外循环(CPB)前后肺动脉压(PAP)及右心功能的变化，并探讨前列腺素E1(PGE1)对CPB后肺高压及右心功能的影响。方法 12条狗随机分为实验组(PGE1组)和对照组，经体外循环60min后观察PAP及右心功能的变化以及PGE1干预作用。结果 CPB后，PAP较CPB前有明显升高，反映右心功能的指标如心输出量(CO)、射血分数(EF)、心指数(CI)等则有明显降低。与对照组相比，PGE1组CPB后PAP明显降低，而右心功能有明显升高，体循环压力在CPB前后两组间无明显差异。结论 CPB可引起肺高压及右心功能的降低，PGE1可以选择性的作用于肺血管，降低肺动脉压力，促进术后右心功能的恢复。
|
| 关 键 词： | 前列腺素E1 体外循环 肺高压 右心功能 |
| 文章编号： | 0258-5898(2000)01-0035-04 |
| 修稿时间： | 1999-06-24 |
Effect of Prostaglandin E1 on Pulmonary Hypertension and Right Heart Functions after CPB |
| |
| HUANG Ritai,ZHU Hongsheng,ZHANG Yourong. Effect of Prostaglandin E1 on Pulmonary Hypertension and Right Heart Functions after CPB[J]. Journal of Shanghai Jiaotong University:Medical Science, 2000, 20(1): 35-38 |
| |
| Authors: | HUANG Ritai ZHU Hongsheng ZHANG Yourong |
| |
| Affiliation: | HUANG Ritai,ZHU Hongsheng,ZHANG Yourong;(Department of Cardio Thoracic Surgery, Renji Hospital, SSMU, Shanghai 200001) |
| |
| Abstract: | Objective To study the pulmonary artery pressure(PAP) and right heart functions after cardiopulmonary bypass(CPB) and the protective effect of prostaglandin E1. Methods Twelve mongrel dogs were randomly divided into two groups: control group (C) and PGE, group (P). After 60min of CPB, the changes of PAP and right heart function were observed. Results The PAP level was much biger than the pre-CPB (P<0.01). Right heart functions, including cardiac output (CO), cardiac index (CI) and eject fraction (EF) were much reduced after CPB(P<0.01). With PGE1 infusion after CPB, the PAP was markedly reduced (P<0.01) whereas the CO, EF and CI were significantly increased (P<0.01), compared with the control group. The systemic pressure was not changed (P>0.05) between the two groups. Conclusion CPB can cause pulmonary hypertension and right heart dysfunction. PGE1s can effectively reduce pulmonary hypertension and increase right heart functions. |
| |
| Keywords: | prostaglandin E1 cardiopulmonary bypass pulmonary hypertension right heart function |
| 本文献已被 CNKI 维普 等数据库收录！ |
