铜针通电治疗血管瘤并发急性溶血

目的 探讨铜针通电治疗血管瘤并发急性血管内[溶血的原因。方法 （1）临床观察1例巨大海绵状血管瘤两次铜针通电治疗均并发严重溶血的全过程。（2）体外实验分别将铜针，铁针和不锈钢针置于健康人枸楷酸抗凝血中，接3－6V直流电30min，在通电前，中，后检测各标本血浆游离Hb值；推血片光镜下观察RBC形态，结果临床病例两次铜针通电治疗均发生严重血管内溶血，体外实验通电后RBC变形破碎，血浆游离Hb明显升高，电压越高，通电时间越长，RBC破坏越严重。结论 铜针通电治疗巨大血管瘤可能并发严重的急性血管内溶血，电流对RBC的直接损伤是导致溶血的主要因素。

Clinical observation and experimental study of acute hemolysis following copper needle electrothrombosis for treating hemangioma

Objective To study the pathogenesis of acute intravascular hemolysis following copper needle electrothrombosis for treating a huge cavernous hemangioma. Methods (1) The full course of severe intravascular hemolysis in a patient with huge cavemous hemangioma treated by copper needle electrontrombosis was observed. (2)In vitro experiment, a copper needle, an iron needle and a stainlss-steel needle were put in citrated anticoagulant healthy blood specimens respectively. The needles were electrified with 3～6 voltages DC for 30 minutes. Then the free hemoglobin of the specimens was tested before,during and after electrfication. The red cell morphology was observed under a light microscope. Results Severe intravascular hemolysis occurred in twice treatments with copper needle electrothrombosis. In vitro experiment showed that erythroclasis occurred after needle electrifying with obvious increasing of free plasma hemoglobin of the specimens. The higher the voltage and the longer the electrification of the needle,the more severe the hemocytocatheresis. Conclusions Severe intravascular hemolysis may happen during copper needle electrothrombosis for treating huge cavernous hemangioma. Red blood cell injury directly caused by electrification is the main factor of intravascular hemolysis.