| 大黄蛰虫丸对动脉粥样硬化模型大鼠内皮功能的影响 |
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| 引用本文： | 张艳慧,司秋菊,郭素丽,王艳娜,王鑫国,王贵娟,江玉娟,曹刚.大黄蛰虫丸对动脉粥样硬化模型大鼠内皮功能的影响[J].中国老年学杂志,2011,31(11). |
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| 作者姓名： | 张艳慧 司秋菊 郭素丽 王艳娜 王鑫国 王贵娟 江玉娟 曹刚 |
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| 作者单位： | 1. 河北医科大学中西医结合学院,河北,石家庄,050091
2. 邢台市人民医院内科 |
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| 基金项目： | 河北省中医管理局，河北省教育厅资助 |
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| 摘 要： | 目的 观察大黄蛰虫丸对血脂、内皮素、内皮舒张因子在动脉粥样硬化(AS)模型大鼠中表达的影响.方法 SD雄性大鼠体重220～300 g,随机分为5组,对照组、模型组、大黄蛰虫丸高剂量组、低剂量组,阳性药组,每组8只,共40只.用高脂饲料喂养,建立大鼠AS模型,用大黄蛰虫丸灌胃12 w后,观察各组大鼠血清血脂,内皮素(ET),一氧化氮(NO) 含量的变化.结果 模型组ET含量显著升高,NO含量显著降低,与对照组比较有显著差异(P<0.05),大黄蛰虫丸组较模型组血清ET含量明显降低,NO含量显著升高(P<0.05).结论 大黄蛰虫丸通过降低血清ET含量,升高血清NO,保护内皮功能,发挥抗AS的作用.
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| 关 键 词： | 动脉粥样硬化 大黄蛰虫丸 内皮功能 |
Effect of Dahuang Zhechong pill on epithelial function of atherosclerosis model mice |
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| ZHANG Yan-Hui,SI Qiu-Ju,GUO Su-Li,et al..Effect of Dahuang Zhechong pill on epithelial function of atherosclerosis model mice[J].Chinese Journal of Gerontology,2011,31(11). |
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| Authors: | ZHANG Yan-Hui SI Qiu-Ju GUO Su-Li |
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| Institution: | ZHANG Yan-Hui,SI Qiu-Ju,GUO Su-Li,et al.School of Integrated Traditional Chinese and Western Medicine,Hebei Medical University,Shijiazhuang 050091,Hebei,China |
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| Abstract: | Objective To observe the level of endothelin(ET),nitric oxide(NO) in atherosclerosis(AS) model mice and investigate anti-AS mechanism of Dahuang Zhechong pill.Methods 40 mice were divided into 5 groups randomly: control,model,low,high dose and Xuezhikang groups.The mice in the control group were fed with normal forage.Others were fed with forage of high cholesterol and injection Vit D3 per 1 kg in 3 days.Mice in control group was given NaCl.After 21 days observing,the mice in control and model groups were f... |
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| Keywords: | ET NO |
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