| 地西泮联合亚低温对大鼠脑缺血损伤病理的影响 |
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| 引用本文： | 邱小鹰,王何,陈红,杨明秀,廖书胜. 地西泮联合亚低温对大鼠脑缺血损伤病理的影响[J]. 中国老年学杂志, 2011, 31(11) |
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| 作者姓名： | 邱小鹰 王何 陈红 杨明秀 廖书胜 |
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| 作者单位： | 1. 广西医科大学第五附属医院神经内科,广西,柳州,545001
2. 桂林医学院附属医院 |
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| 基金项目： | 广西壮族自治区自然科学基金资助项目 |
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| 摘 要： | 目的 探讨地西泮联合亚低温治疗对大鼠局灶脑缺血组织病理损伤的影响.方法 20只Wistar大鼠随机分为假手术组、脑缺血对照组、轻度高温地西泮组、常温地西泮组及亚低温地西泮组(每组4只).用线栓法制作大鼠脑缺血模型,地西泮组在缺血前30 min及缺血后2 h腹腔注射地西泮(10 mg/kg).诱导目标脑温,采用光镜、电镜观察各组病理特点.结果 轻度高温、常温、亚低温状态下地西泮治疗组随脑温降低,缺血脑组织病理损伤依次减轻,地西泮联合亚低温治疗明显改善缺血脑组织病理学特征.结论 地西泮联合亚低温治疗对脑缺血的保护作用增强.
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| 关 键 词： | 脑缺血 地西泮 亚低温 神经保护 神经病理 |
Pathology study of diazepam with subhypothermia on the damage change of cerebral tissue in rat focal cerebral ischemia |
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| QIU Xiao-Ying,WANG He,CHEN Hong,et al.. Pathology study of diazepam with subhypothermia on the damage change of cerebral tissue in rat focal cerebral ischemia[J]. Chinese Journal of Gerontology, 2011, 31(11) |
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| Authors: | QIU Xiao-Ying WANG He CHEN Hong et al. |
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| Affiliation: | QIU Xiao-Ying,WANG He,CHEN Hong,et al.Department of Neurology,the Fifth Affiliated Hospital of Guangxi Medical College,Liuzhou 545001,Guangxi,China |
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| Abstract: | Objective To investigate the effect of diazepam with subhypothermia on the pathology change of cerebral tissue in rat focalcerebral ischemia under different cerebral temperature.Methods Determined at different brain temperature,20 Wistar rats were randomly divided into 5 groups,including the sham operated,cerebral ischemia,cerebral ischemia groups in subhypothermia,Diazepam group in mild,normal temperature,Diazepam group under subhypothermia temperature.The model of rat middle cerebral artery ischemia reper... |
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| Keywords: | Cerebral ischemia Diazepam Subhypothermia Neuroprotection Neuropathology |
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