| 左旋氨氯地平对自发性高血压大鼠胸主动脉重构及内皮功能的影响 |
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| 引用本文： | 王睿,吕吉元,张明升,刘宇,李洁,宋俊丽,张文静.左旋氨氯地平对自发性高血压大鼠胸主动脉重构及内皮功能的影响[J].中国临床药理学杂志,2011,27(4). |
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| 作者姓名： | 王睿 吕吉元 张明升 刘宇 李洁 宋俊丽 张文静 |
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| 作者单位： | 1. 山西医科大学第一医院心内科,太原,030001
2. 山西医科大学药理学教研室,太原,030001 |
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| 摘 要： | 目的 观察左旋氨氯地平(降压药)对自发性高血压大鼠胸主动脉结构及内皮依赖性舒张功能的影响.方法 20只自发性高血压大鼠,分为左旋氨氯地平治疗组和高血压对照组;同周龄WKY大鼠作为正常对照.治疗组,给予左旋氨氯地平(2 mg·kg-1·d-1),12周后,观察胸主动脉对乙酰胆碱和硝普钠的舒张反应,比较各组主动脉中膜厚度及中膜截面积,检测血清一氧化氮、内皮素的水平.结果 同高血压对照组相比,治疗组的胸主动脉对乙酰胆碱的最大舒张反应明显增强,(48.39±14.86)%vs(34.71±9.23)%,P=0.03;胸主动脉中膜厚度及截面积明显减小(P<0.05),血清一氧化氮浓度明显增加(P<0.05).结论 左旋氨氯地平能够改善自发性高血压大鼠血管内皮依赖性舒张功能,抑制血管重构,机制可能与增加一氧化氮的合成和释放有关.
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| 关 键 词： | 自发性高血压大鼠 内皮功能 左旋氨氯地平 |
Effects of S(-)-amlodipine on thoracic aorta remodeling and endothelial function in spontaneously hypertensive rats |
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| WANG Rui,LV Ji-yuan,ZHANG Ming-sheng,LIU Yu,LI Jie,SONG Jun-li,ZHANG Wen-jing.Effects of S(-)-amlodipine on thoracic aorta remodeling and endothelial function in spontaneously hypertensive rats[J].The Chinese Journal of Clinical Pharmacology,2011,27(4). |
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| Authors: | WANG Rui LV Ji-yuan ZHANG Ming-sheng LIU Yu LI Jie SONG Jun-li ZHANG Wen-jing |
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| Institution: | WANG Rui1,LV Ji-yuan1,ZHANG Ming-sheng2,LIU Yu2,LI Jie2,SONG Jun-li2,ZHANG Wen-jing2(1.Department of Cardiology,First Hospital Affiliated to Shanxi Medical University,Taiyuan 030001,China,2.Department of Pharmacology,Shanxi Medical University,China) |
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| Abstract: | Objective To investigate whether S(-)-amlodipine can improve vascular remodeling and vascular endothelial relaxation of spontaneously hypertensive rats(SHR).Methods SHRs were randomly divided into 2 groups: hypertension control group and S(-)-amlodipine group.Age-matched Wistar-Kyoto(WKY) rats served as normal control group.After being treated for 12 weeks,rats were studied to observe the endothelium dependent relaxation of thoracic aorta to acetylcholine(ACh) and sodium nitmpruside(SNP).The average media t... |
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| Keywords: | spontaneously hypertensive rats endothelial function S(-)-amlodipine |
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