血府逐瘀汤治疗慢性乙型肝炎肝纤维化疗效观察

目的 观察血府逐瘀汤治疗慢性乙型肝炎纤维化的临床疗效.方法 选取2011年1月-2012年1月医院收治的64例慢性乙型肝炎肝纤维化患者为研究对象,按照入院顺序随机均分为两组,观察组患者给予口服血府逐瘀汤联合干扰素治疗；对照组患者给予干扰素治疗,疗程3个月,之后观察两组治疗前后血清肝纤维化指标和门静脉血流动力学指标.结果 观察组患者治疗总有效率为90.63％,明显高于对照组(65.63％),差异有统计学意义(P＜0.05)；观察组患者治疗后血清肝纤维化指标Ⅲ型前胶元(PCⅢ)、透明质酸(HA)、层黏蛋白(LN)分别为(131.6±76.5)、(103.7±89.4)、(89.6±21.0)μg/L,治疗前分别为(283.5±153.2)、(322.3±146.1)、(116.3±26.4) μg/L,治疗后较治疗前均明显下降(P＜0.05)；对照组治疗后血清肝纤维化指标PCⅢ、HA、LN分别为(213.4±65.7)、(145.3±92.4)、(99.2±22.7) μg/L,观察组患者治疗后血清肝纤维化指标均低于对照组治疗后(P＜0.05)；观察组治疗后门静脉主干内径(12.9±1.5)mm与治疗前(13.4±1.4)mm比较,差异无统计学意义；治疗后门静脉平均血流速度(20.1±3.1)cm/s,大于治疗前的(17.2±3.5)cm/s,门静脉血流量(815±123)ml/min,小于治疗前的(1032±241)ml/min,差异均有统计学意义(P＜0.05)；对照组治疗后门静脉主干血流动力学各参数与治疗前比较均无明显变化.结论 血府逐瘀汤联合干扰素治疗可改善慢性乙型肝炎肝纤维化患者门静脉平均血流速度、门静脉血流量以及血清肝纤维化指标,值得推广应用.

Clinical efficacy of therapeutic soup in treatment of hepatitis B liver fibrosis

OBJECTIVE To observe the clinical effect of therapeutic soup in the treatment of the patients with hepatitis B liver fibrosis.METHODS From Jan 2011 to Jan 2012,64 patients with chronic hepatitis B liver fibrosis were collected as the research objects,according to the order,all the patients were randomly divided into two groups,the observation group patients were given oral therapeutic soup combined interferon treatment,the control group patients were given interferon therapy,then we observed the serum index of liver fibrosis and portal venous blood flow dynamic index before and after the treatment.RESULTS The total effective rate of the observation group(90.63%) was significantly higher than those of the control group(65.63%),the difference was statistically significant(P<0.05).The serum index of liver fibrosis μg/L of the observation group patients after treatment were significantly lower than before treatment(213.4±65.7,145.3±92.4,99.2±22.7) μg/L(P<0.05).The serum index of liver fibrosis of the observation group patients μg/L were lower than those of the control group after treatment(213.4±65.7,145.3±92.4,99.2±22.7)(P<0.05).There were no significant differences in the portal vein inner diameter of the observation group between before(13.4±1.4) mm and after the treatment(12.9±1.5) mm.The mean portal blood flow velocity after treatment(20.1±3.1) cm/s was higher than before treatment(17.2±3.5) cm/s,the portal flow volume(815±123) ml/min was less than before treatment(1032±241) ml/min,the differences were statistically significant(P<0.05);there were no significant differences in the portal venous blood flow dynamic index of the control group before and after treatment.CONCLUSION Therapeutic soup combined interferon treatment could improve the mean blood flow velocity,the portal flow volume,and serum index of liver fibrosis of the chronic hepatitis B liver fibrosis,which isworthy of the popularization.