慢性重型肝炎及肝硬化患者并发自发性细菌性腹膜炎的临床研究

目的 探讨慢性重型肝炎及肝硬化患者并发自发性细菌性腹膜炎(SBP)的临床特点.方法 对医院2009年1月1日-2011年6月30日的59例慢性重型肝炎及肝硬化并发SBP患者及同时期非SBP患者54例的临床资料进行统计分析.结果 腹水检查SBP组患者腹水多形核白细胞(PMN)比值≥0.50占83.05％,而非SBP比值≥0.50的患者占12.96％,两组比较,差异有统计学意义(x2=9.87,P＜0.01);SBP组药物治疗后治愈率为37.29％.结论 SBP是肝病晚期的严重的并发症,腹水PMN比值是诊断SBP的可靠的指标；最佳的治疗药物为第三代头孢菌素类.

Clinical research on chronic severe hepatitis and liver cirrhosis patients with spontaneous bacterial peritonitis

OBJECTIVE To investigate the clinical features of chronic severe hepatitis and liver cirrhosis patients with spontaneous bacterial peritonitis(SBP).METHODS The clinical data of 59 chronic severe hepatitis and cirrhosis in patients with SBP from Jan 1st 2009 to Jun 30th 2011 and 54 patients with non-clinical SBP at the same period were statistically analyzed.RESULTS The ascites examination showed that the patients with the ratio of ascites polymorphonuclear leukocyte more than 0.50 accounted for 83.5% in the SBP group,while the patients with the ratio of of ascites polymorphonuclear leukocyte more than 0.50 accounted for 12.96% in the non-SBP group,the difference was statistically significant(χ2=9.87,P<0.01);the cure rate of the SBP group was 37.29% after treatment with drugs.CONCLUSION SBP is a serious complication of advanced liver disease,ascites PMN ratio is a reliable indicator for the diagnosis of SBP;the best drug for treatment is the third-generation cephalosporins.